Browsing Mechanical, Manufacturing & Biomedical Eng by Subject "Next Generation Medical Devices"
Now showing items 1-20 of 117
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Age-related responses to injury and repair in insect cuticle
(The Company of Biologists Ltd, 2019)We evaluated the ability of female adult desert locusts (Schistocercagregaria) to repair injuries to their exoskeletons and restore mechanical strength over the course of their natural life. We discovered that younger ... -
Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
(2014)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts ... -
An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue
(2012)Inelastic phenomena such as softening and unrecoverable inelastic strains induced by loading have been observed experimentally in soft tissues such as arteries. These phenomena need to be accounted for in constitutive ... -
The anisotropic mechanical behaviour of passive skeletal muscle tissue subjected to large tensile strain
(2013)The passive mechanical properties of muscle tissue are important for many biomechanics applications. However, significant gaps remain in our understanding of the three-dimensional tensile response of passive skeletal ... -
Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations
(2012)Continuous fibre distribution models can be applied to a variety of biological tissues with both charged and neutral extracellular matrices. In particular, ellipsoidal models have been used to describe the complex material ... -
A Biomechanical and Microstructural Analysis of Bovine and Porcine Pericardium for Use in Bioprosthetic Heart Valves
(2021)Background: Animal-derived pericardium is a key material that enables the successful clinical use of bioprosthetic heart valves. Recently, transcatheter heart valves have placed more emphasis on the enhancement of this ... -
Biomechanical studies of feline ventral abdominal wall and celiotomy closure techniques.
(2018)Objective: To compare biomechanical properties and mechanism of failure of 3 regions of ventral abdominal wall in cats by using 2 suture materials, 2 suture bite‐to‐stitch intervals (SBSI), and full‐thickness versus ... -
Biomechanics of the stick insect antenna: Damping properties and structural correlates of the cuticle
(2011)The antenna of the Indian stick insect Carausius morosus is a highly specialized near-range sensory probe used to actively sample tactile cues about location, distance or shape of external objects in real time. The length ... -
Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue
(2020)Bioprosthetic heart valves (BHVs) are implanted in aortic valve stenosis patients to replace the native, dysfunctional valve. Yet, the long-term performance of the glutaraldehyde-fixed bovine pericardium (GLBP) leaflets ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
(2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model
(2009)Integration of repair tissue is a key indicator of the long-term success of cell-based therapies for cartilage repair. The objective of this study was to compare the in vitro chondrogenic differentiation and integration ...