Browsing Mechanical, Manufacturing & Biomedical Eng by Subject "pH"
Now showing items 1-3 of 3
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Consolidating and re-evaluating the human disc nutrient microenvironment
(2022)Background: Despite exciting advances in regenerative medicine, cell-based strategies for treating degenerative disc disease remain in their infancy. To maximize the potential for successful clinical translation, a more ... -
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation
(2021)Background: Ex vivo disc organ culture systems have become a valuable tool for the development and pre‐clinical testing of potential intervertebral disc (IVD) regeneration strategies. Bovine caudal discs have been widely ... -
Two- and three-dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments
(2022)Background It is well established that the unique biochemical microenvironment of the intervertebral disc plays a predominant role in cell viability and biosynthesis. However, unless the effect of microenvironmental ...