| dc.contributor.author | BOYLAN, FABIO | en |
| dc.date.accessioned | 2017-03-07T15:59:25Z | |
| dc.date.available | 2017-03-07T15:59:25Z | |
| dc.date.issued | 2016 | en |
| dc.date.submitted | 2016 | en |
| dc.identifier.citation | Donald, GR; Fernandes PD; Boylan, F, Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil, Evidence-based Complementary and Alternative Medicine, 1, 1, 2016, 3840398- | en |
| dc.identifier.issn | 1741-427X | en |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study
aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO).Themajor component present in the essential oil was betaphellandrene
(29.39%). Its antinociceptive activity was tested through animalmodels (formalin-, capsaicin-, and glutamate-induced
paw licking and hot plate).The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into
the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the
first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking
induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan. | en |
| dc.description.sponsorship | The authors would like to thank Mr. Alan Minho for the technical assistance and Instituto Vital Brazil (Niterói, Rio de Janeiro, Brazil) for donation of animals used in this study. This work was supported by the National Council for Scientific and Technological Development (CNPq, fellowship to P. D. Fernandes and G. R. Donald and grant support to P. D. Fernandes) and Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ, fellowship to P. D. Fernandes and grant support to P. D. Fernandes). Fabio Boylan wishes to acknowledge the High Education Authority’s Programme for Research in Third-Level Institutions Cycle 5’s funding support for TBSI and to reinforce the importance of SFI programme ISCA-Brazil (Grant no. SFI/13/ISCA/2843), which contributed to the collaborative work between Brazil and Ireland. | en |
| dc.format.extent | 3840398 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Evidence-based Complementary and Alternative Medicine | en |
| dc.relation.ispartofseries | 1 | en |
| dc.relation.ispartofseries | 1 | en |
| dc.rights | Y | en |
| dc.subject | Zanthoxylum piperitum DC. | en |
| dc.subject.lcsh | Zanthoxylum piperitum DC. | en |
| dc.title | Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/desouzaf | en |
| dc.identifier.rssinternalid | 151440 | en |
| dc.identifier.doi | http://dx.doi.org/10.1155/2016/3840398 | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
| dc.subject.TCDTheme | International Integration | en |
| dc.subject.TCDTag | Ethnopharmacology | en |
| dc.subject.TCDTag | PHARMACOLOGY | en |
| dc.subject.TCDTag | Phytochemistry & Natural Products | en |
| dc.identifier.orcid_id | 0000-0001-5531-1787 | en |
| dc.status.accessible | N | en |
| dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
| dc.contributor.sponsorGrantNumber | SFI/13/ISCA/2843 | en |
| dc.identifier.uri | http://hdl.handle.net/2262/79647 | |
