dc.contributor.advisor | Mills, Kingston | |
dc.contributor.author | McManus, Róisín M. | |
dc.date.accessioned | 2017-06-01T16:08:44Z | |
dc.date.available | 2017-06-01T16:08:44Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Róisín M. McManus, 'Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015, pp 340 | |
dc.identifier.other | THESIS 10624 | |
dc.description.abstract | Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, however, it has not been established if these are a consequence of ongoing neurodegeneration or whether inflammation itself contributes to disease pathogenesis. T cells have been reported in the AD brain and clinical trials involving immunization with Aβ induced increased T cell infiltration into the brain and meningoencephalitis in some patients. In this study, the effect of Aβ-specific T cells was assessed in vitro and in vivo. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Biochemistry and Immunology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16185062 | |
dc.subject | Biochemistry & Immunology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 340 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/80346 | |