Exploring the neural substrates contributing to the risk for psychosis : an MRI investigation

Abstract

Over the last three decades schizophrenia research has shifted its focus from studying individuals with the established illness to those who have an elevated risk for developing the disease. Research has suggested that schizophrenia is a neurodevelopmental disorder which may be negatively affected by genetic and environmental insults which may contribute to the neurobiological abnormalities and cognitive deficits observed in schizophrenia patients.