Composite scaffold development and bioreactor culture for bone tissue engineering
Citation:
Niamh Plunkett, 'Composite scaffold development and bioreactor culture for bone tissue engineering', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009, pp 262Download Item:
Abstract:
Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this
construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into a defect site in the body. This is called the tissue engineering triad: combining cells, scaffold and signalling to engineer tissue in vitro. In this work, the focus was on two aspects of the triad: scaffold development and signalling using a bioreactor. The general aim in this work was to develop a tissue engineered construct with enhanced osteogenic capabilities due to its structural and material properties, populated by a homogeneous distribution of stimulated cells.
Author: Plunkett, Niamh
Advisor:
O'Brien, Fergal J.Publisher:
Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing EngineeringNote:
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