| dc.contributor.author | Senge, Mathias | |
| dc.contributor.author | Callaghan, Susan | |
| dc.contributor.author | Filatov, Mikhail A. | |
| dc.contributor.author | Sitte, Elisabeth | |
| dc.contributor.author | Savoie, Huguette | |
| dc.contributor.author | Boyle, Ross W. | |
| dc.contributor.author | Flanagan, Keith J. | |
| dc.date.accessioned | 2019-11-29T10:29:43Z | |
| dc.date.available | 2019-11-29T10:29:43Z | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017 | en |
| dc.identifier.citation | Callaghan, S., Filatov, M.A., Sitte, E., Savoie, H., Boyle, R.W., Flanagan, K.J. & Senge, M.O., Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins, Photochemical and Photobiological Sciences, 16, 9, 2017, 1371-1374 | en |
| dc.identifier.other | Y | |
| dc.description.abstract | A new type of porphyrin photosensitizer capable of generating
singlet oxygen upon irradiation, storing it through binding to
pyridone subunits, followed by slow release at 20‐40 °C is
reported. The timescale of singlet oxygen release can be varied
depending on the pyridone group substitution pattern, forming
endoperoxides of different stability. Modified tetra‐ and octasubstituted
pyridone‐porphyrins showed solubility in water,
allowing for straightforward delivery into cells. The effect of
delayed singlet oxygen formation due to endoperoxide
decomposition was demonstrated on cancer cells in vitro. | en |
| dc.format.extent | 1371-1374 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Photochemical and Photobiological Sciences; | |
| dc.relation.ispartofseries | 16; | |
| dc.relation.ispartofseries | 9; | |
| dc.rights | Y | en |
| dc.subject | Oxygen | en |
| dc.subject | Porphyrins | en |
| dc.subject | Cancer cells | en |
| dc.title | Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | |
| dc.identifier.rssinternalid | 181862 | |
| dc.identifier.doi | http://dx.doi.org/10.1039/c7pp00244k | |
| dc.rights.ecaccessrights | openAccess | |
| dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
| dc.contributor.sponsorGrantNumber | SFI IvP 13/IA/1894 | en |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2017/PP/C7PP00244K#!divAbstract | |
| dc.identifier.uri | http://hdl.handle.net/2262/90924 | |
