Radical-mediated thiol–ene ‘click’ reactions in deep eutectic solvents for bioconjugation
Citation:
Nolan, M.D. and Mezzetta, A. and Guazzelli, L. and Scanlan, E.M., Radical-mediated thiol–ene ‘click’ reactions in deep eutectic solvents for bioconjugation, Green Chemistry, 2022, 24, 4, 1456-1462Download Item:
Abstract:
Herein, we report the first application of deep eutectic solvents
(DESs) in radical-mediated hydrothiolation reactions. Under UV
and atmospheric-oxygen mediated conditions, the thiol–ene reac tion was applied to amino acid and peptide ligation in DESs. The
conditions facilitate highly-efficient synthesis of biomolecular
targets using a ‘green’ methodology, with complete recycling of
the reaction medium. Fluorescent labelling and glycosylation of a
minimal sequence mimetic of angiotensin-converting enzyme 2
capable of binding the SARS-CoV-2 spike protein is demonstrated
for applications in the study of inhibition of COVID-19 infectivity
Author's Homepage:
http://people.tcd.ie/scanlae
Author: Scanlan, Eoin
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Journal ArticleCollections
Series/Report no:
Green Chemistry;24;
4;
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Full text availableDOI:
http://dx.doi.org/10.1039/d1gc03714eMetadata
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