A study of bioenergetics and mitochondrial function in Cytotoxic T cell subsets
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2026-09-30Citation:
Davis, Gavin, A study of bioenergetics and mitochondrial function in Cytotoxic T cell subsets, Trinity College Dublin.School of Biochemistry & Immunology, 2022Download Item:
Abstract:
CD8 T cell fate and function have been linked to specific metabolic programs. T effector (T eff) and T memory (T mem) cells engage mitochondrial metabolism to different extents, as recognised by stark differences in mitochondrial morphology, dynamics and oxidative phosphorylation (Oxphos). CD8 T eff cells are thought to engage aerobic glycolysis to fuel anabolism, while T mem cells engage Oxphos and fatty acid oxidation to satisfy their longevity and self-renewal. However, it is not known the extent to which individual mitochondrial electron transport chain (ETC) complexes control CD8 T cell bioenergetics and function. Therefore, this study aimed to carry out an in-depth bioenergetic analysis of both CD8 T cell subsets, to further understand the fundamental differences between mitochondrial and ETC functions between both subsets.
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Author: Davis, Gavin
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Davey, GavinPublisher:
Trinity College Dublin. School of Biochemistry & Immunology. Discipline of BiochemistryType of material:
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