Synthesis and biological evaluation of novel pyrazolyl 1, 4-dihydropyridines, 1,2,3,4-tetrahydropyrimidines and related compounds as antiproliferative agents

Abstract

This thesis reports the design, synthesis, characterisation and biological evaluation of novel dihydropyridines, tetrahydropyrimidines and structurally related compounds. Therapeutically used as calcium channel blockers (CCBs), 1,4-dihydropyridines are under investigation for antiproliferative effects and potential ability to overcome multidrug resistance (MDR). The expanding interest in the 1,4-dihydropyridine (DHP) and related tetrahydropyrimidine (THP) family is evident from the extensive research and studies perfonned in the area. A review of the literature presents a number of potential uses for DHPs and THPs and focus is placed on their potential as anti-cancer agents in this thesis (Chapterl).