Midlife hypertension is a risk factor for some, but not all, domains of cognitive decline in later life: a systematic review and meta-analysis

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Journal ArticleDate:
2023Access:
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Joyce, Oisín Cormac, McHugh, Clíodhna, Mockler, David, Wilson, Fiona, Kelly, Áine M., Midlife hypertension is a risk factor for some, but not all, domains of cognitive decline in later life: a systematic review and meta-analysis, Journal of Hypertension, 2023Abstract:
Midlife hypertension is a risk factor for some, but
not all, domains of cognitive decline in later life:
a systematic review and meta-analysis
Ois ın Cormac Joyce a
, Cl ıodhna McHugh a , David Mockler b , Fiona Wilson c , and Aine M. Kelly a
Introduction: Management of midlife blood pressure and
hypertension status may provide a window of intervention
to mitigate cognitive decline with advancing age. The aim
of this review was to investigate the relationship between
midlife hypertension and cognition in midlife and later life.
Methods: Online electronic databases were searched from
their inception to May 2022. Studies assessing midlife (40–
65 years) hypertension and cognition at mid and/or later-
life were included. A random effects meta-analysis was
deemed appropriate.
Results: One hundred forty-nine studies across 26
countries were included. Qualitative synthesis found
negative relationships between midlife hypertension and
later life cognition in the domains of memory, executive
function, and global cognition. Metanalytical evidence
revealed midlife hypertension negatively impacts memory,
executive function, and global cognition but had no
observed effect on attention at midlife.
Discussion: Hypertension at midlife has a significant
negative impact on cognition in mid-life and later life,
namely memory, executive function, and global cognition.
Author's Homepage:
http://people.tcd.ie/wilsonfhttp://people.tcd.ie/mocklerd
http://people.tcd.ie/aikelly
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PUBLISHEDPublisher:
Ovid Technologies (Wolters Kluwer Health)Type of material:
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Journal of Hypertension;Availability:
Full text availableDOI:
http://dx.doi.org/10.1097/hjh.0000000000003614ISSN:
0263-6352Metadata
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