Connectome-based predictive modeling of cognitive reserve using task-based functional connectivity

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2022Access:
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Boyle, R., Connaughton, M., McGlinchey, E., Knight, S.P., De Looze, C., Carey, D., Stern, Y., Robertson, I.H., Kenny, R.A. and Whelan, R, Connectome-based predictive modeling of cognitive reserve using task-based functional connectivity, European Journal of Neuroscience, 2022Download Item:
Abstract:
Cognitive reserve supports cognitive function in the presence of pathology or
atrophy. Functional neuroimaging may enable direct and accurate measurement of cognitive reserve which could have considerable clinical potential.
The present study aimed to develop and validate a measure of cognitive
reserve using task-based fMRI data that could then be applied to independent
resting-state data. Connectome-based predictive modelling with leave-one-out
cross-validation was applied to predict a residual measure of cognitive reserve
using task-based functional connectivity from the Cognitive Reserve/Reference
Ability Neural Network studies (n = 220, mean age = 51.91 years,
SD = 17.04 years). This model generated summary measures of connectivity
strength that accurately predicted a residual measure of cognitive reserve in
unseen participants. The theoretical validity of these measures was established
via a positive correlation with a socio-behavioural proxy of cognitive reserve
(verbal intelligence) and a positive correlation with global cognition, indepen-
dent of brain structure. This fitted model was then applied to external test
data: resting-state functional connectivity data from The Irish Longitudinal
Study on Ageing (TILDA, n = 294, mean age = 68.3 years, SD = 7.18 years).
The network-strength predicted measures were not positively associated with
a residual measure of cognitive reserve nor with measures of verbal intelligence and global cognition. The present study demonstrated that task-based
functional connectivity data can be used to generate theoretically valid measures of cognitive reserve. Further work is needed to establish if, and how,
measures of cognitive reserve derived from task-based functional connectivity
can be applied to independent resting-state data.
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European Journal of Neuroscience;Availability:
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Ageing , NeuroscienceDOI:
https://doi.org/10.1101/2022.06.01.494342Metadata
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