Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood

File Type:
PDFItem Type:
Journal ArticleDate:
2018Access:
openAccessCitation:
McCarthy H., Stanley J., Piech R., Wetterling F., Skokauskas N., Mulligan A., Donohoe G., Mullins D., Kelly J., Johnson K., Fagan A., Gill M., Meaney J., Frodl T., Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood, Journal of Attention Disorders, 22, 6, 2018, 561, 570Abstract:
Objective: ADHD persists in up to 60% into adulthood, and the reasons for persistence are not fully understood. The objective of this study was to characterize the neurofunctional basis of decision making in those with a childhood diagnosis of ADHD with either persistent or remitted symptoms in adulthood versus healthy control participants.
Method: Thirty-two adults diagnosed with ADHD as children were split into persistent ( n = 18) or remitted ( n = 14) ADHD groups. Their neural activity and neurofunctional connectivity during a probabilistic reversal learning task were compared with 32 healthy controls.
Results: Remitters showed significantly higher neural connectivity in final reversal error and probabilistic error conditions, and persisters depict higher neural connectivity in reversal errors than controls at a family-wise error (FWE) corrected whole-brain corrected threshold.
Conclusion: Remitters may have utilized higher neural connectivity than controls to make successful decisions. Also, remitters may have utilized compensatory strategies to override any potential underlying ADHD deficits.
Author's Homepage:
http://people.tcd.ie/wetterfhttp://people.tcd.ie/kellyj37
Description:
PUBLISHED
Author: Wetterling, Friedrich; Kelly, John
Type of material:
Journal ArticleSeries/Report no:
Journal of Attention Disorders22
6
Availability:
Full text availableDOI:
https://doi.org/10.1177/1087054716661233Metadata
Show full item recordThe following license files are associated with this item: