Immunology (Theses and Dissertations): Recent submissions
Now showing items 21-31 of 31
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Identification of Schistosoma mansoni adult male worm excretome-secretome and production of recombinant proteins with immunomodulatory potential
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)Over two billion people worldwide are infected with helminth parasites. Helminths strongly modulate the host’s immune response in order to establish a balanced parasite- host dynamic. This helminth-derived immunomodulatory ... -
Immune variation in idiopathic bronchiectasis
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Bronchiectasis is a chronic suppurative lung disease. It is the pathological end-point of many disease processes including cystic fibrosis and antibody deficiency. In many cases of bronchiectasis, termed 'idiopathic', no ... -
Immune responses to tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Coeliac disease is a common inflammatory disease of the small intestine caused by an inappropriate immune response to wheat gluten and gliadin in genetically predisposed individuals. Investigation into the pathogenesis of ... -
Evolutionary origins and functions of Schistosoma mansoni Pellino
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)The immune system of modern man has innate signalling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms, specifically ... -
The characterisation of peripheral blood and intestinal antigen presenting cells in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Antigen presenting cells, part of the innate immune system, play a central role in initiating and modulating the adaptive immune response. Coeliac disease is caused by aberrant activity of T cells specific for the dietary ... -
Design, optimisation and functional relevance of in silico tools for the study of coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Peptide-MHC interaction is a crucial pre-requisite for the recognition of antigen by T cells. It has long been recognised that peptides with a high affinity for MHC molecules are more likely to elicit a pronounced T cell ... -
Characterisation of gut mucosa in patients with potential coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2007)Coeliac disease is a gluten dependent enteropathy with a high incidence and increased risk of mortality. Diagnosis of coeliac disease is based on a biopsy of small intestine. However, it is now believed that many individuals ... -
Hepatic haematopoietic stem cells and the T Cell development potential of the adult human liver
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Large populations of innate T cells are found in the normal adult human liver (AHL), some of which may differentiate locally. The AHL also contains populations of functional myeloid and erythroid progenitors. The co-expression ... -
Innate immunity and coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Coeliac disease is a gluten sensitive enteropathy in which well defined gliadin peptides initiate a T cell mediated inflammatory response within the small intestine. This disseminates into destruction of the villous ... -
Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is an inflammatory disease of the proximal small intestine caused by wheat gluten ingestion in genetically susceptible individuals. The mucosal pathology in coeliac disease is characterised by villous ... -
Molecular events following gluten stimulation in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is a common autoimmune disorder, caused by an intolerance to dietary gluten in genetically predisposed individuals. Despite the advances in understanding of the nature of the disease, it remains unknown how ...
