Browsing Chemistry (Theses and Dissertations) by Date of Publication
Now showing items 21-40 of 398
-
Metallated phosphites and related complexes and their catalytic application
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The orthometallation of triarylphosphite ligands at a palladium centre is described. The formation of the orthometallated palladium dimeric complex [{Pd(μ-Cl){P(OC6H2-2,6-tBu2)(OC6H3-2,4-tBu2)2}}2] 22 is reported and fully ... -
Towards carbohydrate recognition in aqueous media
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)Chapter One provides a brief introduction to supramolecular chemistry. The types of interactions involved in host-guest chemistry are discussed as well as the principles behind the design of a receptor. Chapter Two examines ... -
Studies towards oligodeoxynucleotide conjugates as potential photoactive antisense agents in chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The research presented in this thesis concerns the synthesis of oligodeoxynucleotide (ODN) conjugates and their use in the photochemical induction of oxidative damage to specific nucleic acid bases in a complementary ODN ... -
Studies on the synthesis and reactivity of 2-cyanoacrylate esters and 2-cyanoacrylic acid
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)This thesis is about studies carried out on the synthesis and reactivity of 2- cyanoacrylic acid and 2-cyanoacrylate esters, and is divided into four chapters. Chapter 1 provides an introduction and includes a complete ... -
Investigations of the potential use of ruthenium-ODN conjugates as antisense agents in chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The work presented in this thesis describes the synthesis of two ruthenium oligodeoxynucleotide (ODN) conjugates and their application as potential photoactive antisense agents in a model Chronic Myeloid Leukaemia (CML) ... -
Synthesis and photochemical reactions of 6-alkenyl-3-phenylcyclohex-2-enones
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The synthesis and photochemical reactions of a series of molecules containing both the 3-phenylcylohexenone moiety and an C-6 substituted alkenyl side chain (2- propenyl, 3-butenyl and 4-pentenyl) are described. The C-6 ... -
Synthesis and characterisation of nanocrystalline ZnO for electronic applications
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The main focus of this work was to develop novel industrially viable procedures, based on sol gel technology, for the preparation of nano-size doped ZnO materials for varistor applications. Initially three well-established ... -
Early and late transition metal comlexes incorporating p-Block oxo-anions
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The research presented in this thesis lies within the general area of supramolecular and coordination chemistry. More specifically, this project involved the synthesis of early and late transition metal complexes incorporating ... -
The evaluation of Carbotrap-B and Carbosieve SIII for volatile organic compounds sampling applications that use thermal desorption-gas chromatography as the analytical technique
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The effects of concentration, temperature and humidity on the value of breakthrough volumes (Vb) for forty-four volatile organic compounds (VOC) on Carbotrap-B have been determined using the frontal chromatography method. ... -
Synthesis and physical studies of luminescent lanthanide and colorimetric chemosensors for ions and molecules
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)This thesis, entitled "Synthesis and physical studies of luminescent lanthanide and colorimetric chemosensors for ions and molecules" is divided into six chapters. Chapter One, the introduction, includes a brief summary ... -
The synthesis of prodrugs derived from PaTrin-2
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)Chemotherapeutic alkylating agents, like triazenes and nitrosoureas, whose mechanism of action involves the modification of guanine residues at the 06 -position in DNA are often rendered ineffective by the repair enzyme ... -
Novel photophysical and sequence based probes for DNA
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The aim of this research project was to develop novel DNA photophysical and sequence based probes. The sequence based probes were designed to target the diagnostic bcr/abl sequence of the Philadelphia chromosome that is ... -
Enantioselective receptors via one-bead one-compound combinatorial libraries
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)Chapter 1 describes the overall aim of this project, which is to extend the range of steroid-based receptors synthesised by the Davis group, using the combinatorial chemistry approach instead of traditional design and ... -
Aspects of supramolecular chemistry : molecular helicates and coordination polymers
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The research presented in this thesis lies within the general area of supramolecular and coordination chemistry. There are two facets to the work presented herein. Firstly, the syntheses and characterisation of novel ... -
Synthesis and biological evaluations of novel 1,8-naphthalimide based anti-cancer agents
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)This thesis, titled "Synthesis and Biological Evaluations of Novel 1,8-Naphthalimide based Anti-Cancer Agents" is divided into six chapters. The first chapter, the introduction includes firstly a brief examination of cancer, ... -
The synthesis and photochemistry of some 3-phenylenones
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The excited triplet state of 3-phenylcyclohexenone has been studied by laser flash photolysis and time-resolved infrared spectroscopy. Laser flash photolysis has been used to determine rate constants of decay of excited ... -
Acylative cleavage of some cyclic ethers and study of a novel potassium complex
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)Chapter 1 describes ring-opening reactions of cyclic ethers that are described in the literature. The extensive work carried out on tetrahydrofuran is discussed, but it is noted that reactions involving 2,5-dihydrofuran ... -
Novel macrocyclic and acyclic ligands for metal ion coordination - design, synthesis and physical evaluation
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)Supramolecular chemistry is a relatively young discipline dating back to the late 1960s and early 1970s and, as such, is a highly diverse and dynamic field incorporating organic, inorganic and physical chemistry. Much of ... -
Fluorescent photoinduced electron transfer sensing of anions using charge neutral chemosensors
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The primary aim of this research was to design, synthesise and analyse anion sensors using fluorescence detectors. The thesis is spread over five chapters. Chapter one, the introduction begins with a brief back round to ... -
Nitrogen containing aromatic ligands : nitrogen-heterosuperbenzene and derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)In Chapter 1, the potentially terdentate C,N,N' chelating monoanionic aryl diamine ligand "Diam" is manipulated, resulting in the synthesis of several novel compounds. This includes DiamZnEt, the first organometallic complex ...