Chemistry (Theses and Dissertations): Recent submissions
Now showing items 241-260 of 435
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Mathematical modelling of diffusion in physico-chemical systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)The purpose of this thesis was to investigate the usefulness of mathematical modelling as an aid to understanding the physico chemical processes of iontophoresis in transdermal drug delivery and electrochemical sensor ... -
Cyclen-based lanthanide complexes as ribonuclease mimics
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)This thesis, entitled "Novel Cyclen-based Lanthanide Complexes as Ribonuclease Mimics" is divided into six chapters. Chapter One introduces the field of mRNA cleavage, with emphasis on the hydrolysis of phosphodiesters. ... -
The immobilisation of TiO2 in various heterogeneous hosts for the photocatalytic oxidation of cyanide
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)The main focus of this study lies in the preparation and characterisation of TiO2. The formation of a nanoparticulate semiconductor may offer interesting photophysical properties and have applications as a photocatalyst. ... -
Bioremediation of unresolved complex mixtures in marine oil spills : an analytical perspective
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)Unresolved complex mixture (UCM) is the fraction of some petroleums that cannot be resolved by conventional gas chromatography and is characteristic of biodegraded petroleum oils and some refined products such as lubricating ... -
Synthesis of lactones from tetrahydrofuran derivatives and study of some translactonisation reactions
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The research undertaken in the present study focuses on the synthesis of lactones via the intramolecular acylative cleavage reactions of tetrahydroflirain derivatives. The thesis is divided into a number of sections: an ... -
New studies in the synthesis and applications of pteridines
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The work described in this thesis involved the study of two distinct areas of research within pyrimidine and pteridine chemistry. The first of these involved investigation of the pteridine biosynthetic pathway within the ... -
Synthesis and physical studies of luminescent lanthanide and colorimetric chemosensors for ions and molecules
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)This thesis, entitled "Synthesis and physical studies of luminescent lanthanide and colorimetric chemosensors for ions and molecules" is divided into six chapters. Chapter One, the introduction, includes a brief summary ... -
Chiral hypernucleophilic acylation catalysts and synthesis of bipyridyls via palladium-catalysed reductive homocoupling of chloropyridines
(Trinity College (Dublin, Ireland). School of Chemistry, 2001)Chapter 1 of this thesis discusses the explosion of interest in the non-enzymatic kinetic resolution of secondary alcohols catalysed by chiral derivatives of the hypemucleophilic acylation catalyst, 4-dimethylaminopyridine. ... -
Enantioselective receptors via one-bead one-compound combinatorial libraries
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)Chapter 1 describes the overall aim of this project, which is to extend the range of steroid-based receptors synthesised by the Davis group, using the combinatorial chemistry approach instead of traditional design and ... -
Towards a comprehensive system for the recognition of double helical DNA : Components for base pair recognition in the major groove
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)This thesis describes the attempted synthesis of sequence selective double-stranded DNA-binding ligands. It had been intended to provide a comprehensive DNA recognition system via two different tricyclic heterocyclic motifs. ... -
Investigations of the potential use of ruthenium-ODN conjugates as antisense agents in chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The work presented in this thesis describes the synthesis of two ruthenium oligodeoxynucleotide (ODN) conjugates and their application as potential photoactive antisense agents in a model Chronic Myeloid Leukaemia (CML) ... -
Synthesis of novel 1,8-naphthalimide derivatives : from the development and biological evaluation of anticancer agents to fluorescent and colorimetric anion chemosensors
(Trinity College (Dublin, Ireland). School of Chemistry, 2004)This thesis entitled "Synthesis of Novel 1,8-Naphthalimide Derivatives: From the Development and Biological Evaluation of Anticancer Agents to Fluorescent and Colorimetric Anion Chemosensors" is divided into six chapters, ... -
Nitrogen containing aromatic ligands : nitrogen-heterosuperbenzene and derivatives
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)In Chapter 1, the potentially terdentate C,N,N' chelating monoanionic aryl diamine ligand "Diam" is manipulated, resulting in the synthesis of several novel compounds. This includes DiamZnEt, the first organometallic complex ... -
Fluorescent photoinduced electron transfer sensing of anions using charge neutral chemosensors
(Trinity College (Dublin, Ireland). School of Chemistry, 2003)The primary aim of this research was to design, synthesise and analyse anion sensors using fluorescence detectors. The thesis is spread over five chapters. Chapter one, the introduction begins with a brief back round to ... -
Studies on the synthesis and reactivity of 2-cyanoacrylate esters and 2-cyanoacrylic acid
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)This thesis is about studies carried out on the synthesis and reactivity of 2- cyanoacrylic acid and 2-cyanoacrylate esters, and is divided into four chapters. Chapter 1 provides an introduction and includes a complete ... -
The evaluation of Carbotrap-B and Carbosieve SIII for volatile organic compounds sampling applications that use thermal desorption-gas chromatography as the analytical technique
(Trinity College (Dublin, Ireland). School of Chemistry, 2002)The effects of concentration, temperature and humidity on the value of breakthrough volumes (Vb) for forty-four volatile organic compounds (VOC) on Carbotrap-B have been determined using the frontal chromatography method. ... -
A study of anionic drug transport processes governing passive and enhanced transdermal delivery
(Trinity College (Dublin, Ireland). School of Chemistry, 2001)The research contained herein is directed at defining some of the factors which govern the passive and enhanced transdermal transport of anionic drugs and will extend current knowledge which largely pertains to the analogous ... -
Studies on the synthesis of functionalised lactones
(Trinity College (Dublin, Ireland). School of Chemistry, 2005)The research carried out in the present study focuses mainly on the synthesis of lactones via the acid-catalysed intramolecular acylative cleavage reactions of tetrahydrofuran derivatives. This thesis is divided into four ... -
Towards a comprehensive system for the recognition of double helical DNA : components for T and A
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)This thesis gives an account of the attempted synthesis of sequence selective double stranded DNA ligands. Two distinctive ligands types were envisaged, a pyrrolo[2', 3': 4, 5] thieno [2, 3-d]imidazole system (1.40 and ... -
Synthesis and reactions of new pyrimidines containing functionalised side chains
(Trinity College (Dublin, Ireland). School of Chemistry, 2000)Thin layer chromatography was carried out using Merck Kiesgel 60 F254 0.2 mm silica gel plates. Visualisation was by means of ultra violet light at 254 nm or by development in potassium permanganate solution. Flash ...
