Chemistry (Scholarly Publications): Recent submissions
Now showing items 281-300 of 931
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Hydrogels: Soft matters in photomedicine
(2019)Photodynamic therapy (PDT), a shining beacon in the realm of photomedicine, is a non‐invasive technique that utilizes dyebased photosensitizers (PSs) in conjunction with light and oxygen to produce reactive oxygen species ... -
Trends and targets in antiviral phototherapy
(2019)Photodynamic therapy (PDT) is a well‐established treatment option in the treatment of certain cancerous and pre‐cancerous lesions. Though best‐known for its application in tumor therapy, historically the photodynamic ... -
Functionalization of Deutero- and Protoporphyrin IX Dimethyl Esters via Palladium-Catalyzed Coupling Reactions
(2019)Herein, we report the functionalization of the β-positions of deutero- and protoporphyrin IX dimethyl ester. Initial halogenations were carried out on both deutero- and protoporphyrin IX dimethyl ester. While previously ... -
Not Your Usual Bioisostere: Solid State Study of 3D Interactions in Cubanes
(2019)Previous studies by Desiraju and co-workers have implicated the acidic hydrogen atoms of cubane as a support network for hydrogen-bonding groups. Herein we report a detailed structural analysis of all currently available ... -
Highly Efficient One-Dimensional Triplet Exciton Transport in a Palladium-Porphyrin-Based Surface-Anchored Metal-Organic Framework
(2019)Efficient photon harvesting materials require easy-to-deposit materials exhibiting good absorption and excited-state transport properties. We demonstrate an organic thin-film material system, a palladium-porphyrin based ... -
Incremental Introduction of Organocatalytic Activity into Conformationally Engineered Porphyrins
(2019)To study the correlation of macrocycle nonplanarity and catalytic activity of free base porphyrins in detail, a series of six tetraphenylporphyrins with graded degree of β‐ethyl substitution (“H2EtxTPPs” 1–6; x = 0, 2, 4, ... -
In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy
(2019)The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad ... -
Molekulares Engineering freier Porphyrinbasen als Liganden – das N-H···X-Bindungsmotiv in Tetrapyrrolen
(2019)Die N‐H‐Einheiten im Kern planarer Porphyrine sind oft nicht zugänglich, um Wasserstoffbrückenkomplexe mit Akzeptormolekülen zu bilden. Dies liegt daran, dass die funktionellen Aminogruppen durch das makrozyklische System ... -
[2 + 2 + 2] cyclotrimerisation as a convenient route to 6N-doped nanographenes: A synthetic introduction to hexaazasuperbenzenes
(2017)6N-containing polyphenylene precursors were generated via [2 + 2 + 2] cyclotrimerisation. On methoxy substitution complete ring-closure can be achieved (via FeCl3-mediated oxidative cyclodehydrogenation) to give asymmetric ... -
Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents
(2017)An approach is described to access 1,2,3‐triazole‐derived peptidyl vinyl sulfones as Trypanosoma brucei brucei inhibitors by using click chemistry, starting from a common azide intermediate. Among the triazole analogues, ... -
Perfluorinated phosphine and hybrid P-O ligands for Pd catalysed C-C bond forming reactions in solution and on Teflon supports
(2019)The synthesis of two types of phosphine ligands that feature perfluorinated ponytails is reported. A bidentate (RfCH2CH2)2PCH2CH2P(CH2CH2Rf)2 (Rf = CF3(CF2)n; n = 5, 7) and an alkoxyphosphine made by ring opening a fluorous ... -
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
(2017)Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the ... -
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
(2020)The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making ... -
Conformational Re-engineering of Porphyrins as Receptors with Switchable NH???X-Type Binding Modes
(2019)The selectivity and functional variability of porphyrin cofactors are typically based on substrate binding of metalloporphyrins wherein the pyrrole nitrogen units only serve to chelate the metal ions. Yet, using the porphyrin ... -
Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A
(2018)Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in ... -
Methods for detection of cytosine and thymine modifications in DNA
(2018)Methylation of cytosine at the 5-position is a common epigenetic modification in mammalian DNA and plays an important role in regulating gene expression. Oxidized derivatives of 5-methylcytosine were discovered recently, ... -
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
(2019)We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPFERCC1, with a view to ... -
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
(2019)Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a ... -
Preparation and Characterisation of a Bis‐μ‐Hydroxo‐NiIII2 Complex
(2019)Hydroxide‐bridged high‐valent oxidants have been implicated as the active oxidants in methane monooxygenases and other oxidases that employ bimetallic clusters in their active site. To understand the properties of such ... -
A MnIIMnIII-Peroxide Complex Capable of Aldehyde Deformylation
(2019)Ribonucleotide reductases (RNRs) are essential enzymes required for DNA synthesis. In class Ib Mn2 RNRs superoxide (O2.−) was postulated to react with the MnII2 core to yield a MnIIMnIII‐peroxide moiety. The reactivity of ...
