In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy
![Thumbnail](/themes/edepositireland/images/white_rectangle.jpeg)
File Type:
PDFItem Type:
Journal ArticleDate:
2019Access:
openAccessCitation:
Callaghan, S., Filatov, M.A., Savoie, H., Boyle, R.W. & Senge, M.O., In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy, 2019, Photochemical and Photobiological Sciences, 18, 2Download Item:
Abstract:
The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light.
URI:
https://pubs.rsc.org/en/content/articlelanding/2019/PP/C8PP00402A#!divAbstracthttp://hdl.handle.net/2262/91438
Sponsor
Grant Number
Science Foundation Ireland
vP 13/IA/1894
Author's Homepage:
http://people.tcd.ie/sengemSponsor:
Science Foundation IrelandType of material:
Journal ArticleURI:
https://pubs.rsc.org/en/content/articlelanding/2019/PP/C8PP00402A#!divAbstracthttp://hdl.handle.net/2262/91438
Collections
Series/Report no:
Photochemical and Photobiological Sciences;18;
2;
Availability:
Full text availableDOI:
http://dx.doi.org/10.1039/C8PP00402AMetadata
Show full item recordLicences: