Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 321-333 of 333
-
Computational approaches to the display and manipulation of metabolic pathways : theory and practice
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)Since metabolic pathways constitute a complex system, a mathematical description, even a structural one, must be simplified. Yet, the model must be sufficiently general so that it will encompass the system that is to be ... -
Serotonin transporter ligands as anticancer agents : investigations into a mechanism-based therapy for Burkitt's lymphoma and related malignancies
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The recent discovery that some serotonin transporter (SERT) ligands have the potential to act as pro-apoptotic agents in Burkitt’s lymphoma adds greatly to their diverse pharmacological application and is the primary focus ... -
HCV evasion of IFN-alpha signalling : implications for therapy
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Successful anti-viral immunity is dependent on effective activation of the innate immune response. The majority of individuals infected with hepatitis C virus (HCV) fail to eliminate the virus and progress to chronic ... -
Regulatory T cell induction and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production ... -
Differential patterns of gene expression associated with metastasis in colon cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Metastatic spread is the main cause of colon cancer related death and therefore a greater understanding of this process is a prerequisite for improved treatment. The acquisition of metastatic properties confers tumour cells ... -
Mutational and phenotypic analysis of hyperphenylalaninaemia in Southern Ireland
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Phenylketonuria (PKU) is the most common inherited defect of amino acid metabolism in the Irish population occurring at a frequency of 1/4,500 live births. It is caused by a deficiency of the hepatic enzyme Phenylalanine ... -
T cells in experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Multiple sclerosis (MS) is an intlammatory, demyelinating disease of the central nervous system (CNS) that is both clinically and pathologically heterogeneous. Studies in experimental autoimmune encephalomyelitis (EAE), ... -
Nerve terminal bioenergetics and control of neurotransmitter release
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Mitochondrial dysfunction has been shown to develop as part of the aging process and has been implicated in chronic neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis ... -
Differential patterns of gene expression associated with microsatellite instability and chromosomal instability in colorectal cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)Two distinct pathways exist in sporadic colorectal cancer. The microsatellite instability pathway (MIN) is recognised by widespread instability caused by aberrant mismatch repair machinery. This genotype accounts for 15% ... -
In vitro and in vivo studies on the neuropeptide thyrotropin-releasing hormone (TRH)
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Thyrotropin-releasing hornnone (pyroglutamyl-histidyl-prolineamide; TRH), a tripeptide, a hypothalamic-pituitary-thyroid axis hormone, has neuromodulatory properties and is found in the brain in locations where it has no ... -
Modulation of T cell responses by manipulating signalling pathways in dendritic cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Heat labile enterotoxin from E. Coli (LT) is a powerful vaccine adjuvant, capable of enhancing Th1 and Th2 responses to co-administered antigens. The present study demonstrates that LT also promotes the induction of Th17 ... -
Metabolic control analysis and mitochondrial function in the nerve terminal
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Reduced activities of the mitochondrial electron transport chain complexes have been implicated in the pathogenesis of numerous neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and ... -
Cytidine Aminohydrolase
The object of this work was to gain some information about the mechanics of action of cytidine aminohydralase from sheep liver
