Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 301-320 of 333
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Systemic and local immune responses associated with subclinical endometritis in the postpartum diary cow
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Activation of local innate immune mechanisms by postpartum bacterial contamination of the uterus occurs in all cows and approximately 30% develop endometritis associated with persistent bacterial infection, inflammation ... -
The human hepatocellular immune system and its role in regulating cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)The liver is an essential immunological organ receiving antigen-rich blood directly from the gut; a continuous immune exposure that requires careful immunosurveillance. It is considered to be a mainly tolerogenic organ as ... -
Natural killer cells in the Irish : investigating receptor expression and potential role in psoriasis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)NK cells are granular lymphocytes which act as part of the innate immune system. Their activity is controlled through a balance of signals from inhibitory and activating receptors, with one important family of receptors ... -
Characterisation of T cell responses during Staphylococcus aureus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ... -
DHX9 : novel roles in cytokine induction and its antagonism by vaccinia virus protein E3
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Vaccinia virus (VACV) is a dsDNA virus, which replicates in the cytoplasm of infected host cells. VACV, similar to other viruses, is detected by host innate immunity mainly by sensing of viral nucleic acids such as dsRNA, ... -
An integrated approach to oral vaccination against enteric pathogens
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)While the majority of human pathogens infect the body through mucosal sites, most licenced vaccines are injectable. In fact the only mucosal vaccine that is widely used for infant and childhood vaccination programs is the ... -
An investigaton of the innate immune response to the vaccine adjuvant chitosan
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Vaccination is widely regarded as one of the most successful medical intervention strategies to have been introduced. Despite its resounding success, significant challenges in the field of vaccine research still remain. ... -
Analysis of mitochondrial proteomes and supercomplex structures in brain tissue
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Mitochondria play a complex multifactorial role in the control of cell bioenergetics. A primary function of mitochondria is the production of adenosine 5'-triphosphate (ATP) by the process of oxidative phosphorylation that ... -
The role of Mal in alveolar macrophage-mediated resistance to Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)There is a global resurgence in pulmonary infection with Bordetella pertussis, the causative agent of whooping cough. B. pertussis is known to encode a number of virulence factors, some of which can function as pathogen-associated ... -
The pathogenicity and regulation of CD161⁺Th17 lineage cells in rheumatoid arthritis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Pathogenic Th17 cells, which produce their signature cytokine IL-17, play a key role in autoimmune diseases such as rheumatoid arthritis (RA) and therefore, have been the target of recently developed therapeutics. On the ... -
A role for eIF4A1 in IL-10 induction by LPS
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ... -
Derivation of dopaminergic neurons from embryonic and induced pluripotent stem cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Dopamine (DA) neurons have several fundamental functions in the brain, dysfunction of which has been implicated in neurological and psychiatric disorders, including Parkinson’s disease (PD) and schizophrenia. Embryonic ... -
Immune regulation by interferon-beta in multiple sclerosis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Interferon (IFN)-β is a commonly used therapy for patients with relapsing remitting multiple sclerosis (RRMS). Although IFN-β has been shown to exert various immunomodulatory effects, the therapeutic mechanisms are still ... -
Bioenergetics and mitochondrial dynamics in cancer cells and neurons
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Mitochondria in mammalian cells exist as a highly dynamic and interconnected reticulum. This reticular ultrastructure is defined by the opposing forces of fission and fusion, mainly mediated by a group of large GTPases ... -
The role of NK cells in the immune response to fungal-derived components
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Natural Killer (NK) cells are cells of the innate immune system with effector functions that are best known for their ability to kill cancer or virally infected cells. However, evidence is emerging to support a role for ... -
The role of T cells in the pathogenesis and prevention of the inflammatory and neurodegenerative changes associated with Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Alzheimer’s disease (AD) is a neurodegenerative disease, which is characterised by deposition of amyloid-beta (Aβ)-containing plaques and also by neuroinflammatory changes, typified by an increase in proinflammatory cytokine ... -
Investigation of the mechanism of action and the therapeutic potential of peptides derived from the vaccinia virus protein A46
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)The innate arm of the mammalian immune system employs a number of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognise pathogen associated molecular patterns (PAMPs) and initiate ... -
Evolution of human Natural Killer cell receptors
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Natural Killer (NK) cells are key components of the innate immune system which function in identifying and destroying aberrant or infected cells. They also play active roles in human reproduction. These functions are largely ... -
Manipulating regulatory responses in antitumour immunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The immune system has evolved tolerogenic and regulatory mechanism to control responses to self-antigens and to ensure that the inflammatory immune response to pathogens does not cause excessive tissue damage during ... -
Immunotherapeutics & vaccine adjuvants for cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)It is well established that innate immune responses not only mediate immunity to infection, but also promotes adaptive immunity to pathogens and tumours. Dendritic cells (DC) play a critical role as antigen presenting cells ...
