Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 41-60 of 333
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The role of tissue resident memory T cells in the respiratory mucosal immune response in humans
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, School of Biochemistry and Immunology, 2024)Tissue resident memory T (TRM) cells represent a population of effector memory T cells that persist in peripheral tissues and act as sentinels of the adaptive immune response, facilitating rapid and specific immune responses ... -
NOX2-mediated regulation of NLRP3 inflammasome activation in traumatic brain injury
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Traumatic brain injury (TBI) is described as damage to the brain due to a mechanical impact to the head and is the leading cause of death and disability in developed countries. Following the primary mechanical injury, ... -
Quantitative proteomics of natural dendritic cell subsets
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Dendritic cells (DCs) are a critical bridge between innate and adaptive immunity. They are a heterogeneous population composed of various subsets that modulate different aspects of the immune response. It is now clear that ... -
Investigating the Impact of Non-Structural Proteins of Coronaviruses (CoVs), MERS-CoV & SARS-CoV-1, upon the antiviral Interferon-α JAK/STAT Pathway
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- 2) highlights the need for greater understanding of the immune evasion mechanisms used by CoVs to subvert antiviral responses. CoVs have ... -
Metabolic and redox regulation of IL-17-producing γδ T cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Interleukin-17 (IL-17) is a proinflammatory cytokine that contributes to a wide range of immune responses, including host defence, tissue repair, autoimmune inflammation, and tumour progression. γδ17 T cells (CD3+TCRδ+CD27-) ... -
The function and regulation of IL-17A-producing T cell subsets in central nervous system autoimmunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Multiple sclerosis (MS) is a chronic progressive autoimmune disease of the central nervous system (CNS). MS is characterised by the presence of demyelinating lesions in the CNS and is the leading cause of disability among ... -
Effect of small molecules modulators of Complex III of the electron transport chain on cytokine production in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Innate immune cells promote inflammation when activated by Pathogen- associated molecular patterns (PAMPs) and initiate the immune response to stress and microbial invasion. When macrophages are primed with the ... -
Investigating sex differences in the mitochondria of CD4+ and CD8+ T lymphocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Sex differences in immunity have been observed in many contexts including infectious diseases, cancer, and autoimmunity. Females generally mount stronger innate and adaptive responses, and as a result tend to have lower ... -
Unravelling the inflammatory landscape of hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease characterised by painful lesions at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Follicular ... -
Studying the inhibitory effect of oxysterols on NK-92 metabolism and cytotoxicity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)NK cell-based immunotherapy has become a promising cancer treatment for cancer. One approach is the use of NK cell lines such as NK-92 as this overcomes many of the technical challenges associated with the use of human NK ... -
Delineating the mechanisms utilised by Staphylococcus aureus to survive intracellularly within phagocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major human pathogen in addition to being an important part of the human microbiome. The bacterium has evolved a large array of immune evasion mechanisms to facilitate its persistence ... -
Antiviral activity of human hepatocytes and its regulation by cellular antioxidant systems
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Although several antiviral strategies have been developed in the last decade, hepatotropic viruses are still a significant public health burden, with more than 300 million people being affected worldwide. Hepatocytes, the ... -
Immunopathological features of early age cancer: microsatellite instability in colorectal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Title: Immunopathological features of early age cancer: microsatellite instability in colorectal cancer Background and hypothesis Deciphering the interplay between tumour biology and the immune system may aid the design ... -
Investigation of Staphylococcus aureus-induced immunosuppression during nasal colonisation and the implications for vaccine function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major part of the natural human microbiome, primarily colonising the anterior nares. The overall aim of this project was to determine the impacts nasal colonisation has on local and ... -
Oxysterols - new players in regulation of Natural Killer cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Natural Killer (NK) cells are cytotoxic, innate lymphocytes that play a crucial role in mediating viral and tumour responses as well as supporting tissue homeostasis. Due to their fast acting immune response independent ... -
Innate immune phenotype variation in bovine health and disease
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Infectious diseases are estimated to cost the global agriculture industry $300 billion annually and present significant challenges to animal welfare. Disease burden in cattle and other livestock species also threaten ... -
Investigation of the PTP4A3 oncogene and how it mechanistically regulates autophagy in ovarian cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Ovarian cancer has the highest mortality rates of all gynaecologic malignancies. High mortality rates are associated with poor levels of early detection due to asymptomatic tumour growth and limited screening programmes. ... -
Investigation into the Molecular Mechanisms Underlying Chemoresistance in Malignant Rhabdoid Tumours
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Malignant rhabdoid tumour (MRT) is a rare and aggressive paediatric malignancy associated with poor prognosis and is, unfortunately, highly refractive to treatment. One of the major issues when treating MRT patients is the ... -
Adaptive Expression of Forgotten Engrams
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Long-term memories are stored as stable configurations of neuronal ensembles, termed engrams. While investigation of engram cell properties and functionality in memory recall has been extensive, less is known about how ... -
Role of the Elongator complex in innate immune responses of macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The innate immune system functions as the first line of defence against pathogen infection. Innate immune systems are functionally present across the animal kingdom and mediate host defence against infection via a myriad ...
