Biochemistry (Theses and Dissertations): Recent submissions
Now showing items 61-80 of 333
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Identification of Anticoagulant Properties of Dimethyl Fumarate and 4-Octyl Itaconate via Suppression of the Macrophage Type I Interferon-Tissue Factor Axis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The host response to infection is characterized by activation of the innate immune and blood coagulation systems, which collectively detect, neutralize, and prevent dissemination of the invading pathogen, maintaining ... -
The antiviral potential of itaconate and its derivative 4-Octyl itaconate against RNA viruses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Itaconate is a Krebs cycle derived metabolite which has been shown to have anti-inflammatory properties. This specially applies to derivatives of itaconate, notably the cell permeable analogue 4-octyl itaconate (4-OI) which ... -
Investigating the Signalling and Function of C5aR2
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Complement component 5a receptor 2 (C5aR2) is an enigmatic receptor for anaphylatoxin C5a. It was initially thought to be a decoy receptor, competitively binding to C5a to negatively regulate C5aR1 signalling. However, ... -
Understanding the mechanism and functional effects of caspase-11 regulated nitric oxide production during inflammation and cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Inflammatory caspases are a group of cysteine aspartic proteinases essential for the inflammatory process, but when dysregulated are implicated in inflammatory diseases and cancer-associated chronic inflammatory events. ... -
Particulate adjuvants for use in cancer vaccination
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)It is estimated that 1 in 2 people will develop cancer in their lifetime, highlighting the urgent need for improved preventative and therapeutic strategies. Cancer immunotherapy has emerged as a key pillar of cancer ... -
Investigating the Role of TLR8 in Inflammatory and Antiviral Responses in Human Polymorphonuclear Leukocytes (PMNs)
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023) -
Characterization of Staphylococcal protein A cellular interactions to facilitate its development as a vaccine antigen
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The development of a vaccine from bench to bedside is a lengthy and complex process, which is so rarely fully realized and followed throughout. During the course of this project, we have been able to follow the development ... -
Innate immune activity in endometrial epithelial cells: implication for female fertility
The maternal local immune system is key to a successful pregnancy. Maternal immunity is required to initiate pregnancy related processes, whilst controlling and being active against any infections or malignancies that may ... -
Mechanisms of gasdermin pore formation in response to viral sensing in human respiratory epithelial cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)A key component of the innate immune response to infection or cellular stress is the activation of inflammasomes which leads to gasdermin (GSDM) pore formation, interleukin-1β (IL-1β) release and lytic cell death. GSDMs ... -
Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ... -
Innate immune potential of bovine respiratory epithelial cells: role in viral infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory epithelial cells have important defence activities against respiratory viruses. While their physical barrier function is well described, the molecular mechanisms responsible for how epithelial cells initiate, ... -
NLRP1 drives inflammasome responses in the human respiratory epithelium
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The airway epithelium is now considered crucial to the orchestration of respiratory inflammatory responses and tissue remodelling. It functions as the first line of defence against inhaled concomitants and coordinates the ... -
Adrenergic, Circadian, and Dietary Regulation of Interleukin-17A Expression by Adipose Gamma-Delta T Cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Adipose tissue is home to a unique population of IL-17A expressing Gamma-Delta T cells (Gamma-Delta17 T cells), which are necessary for maintaining body temperature during cold environmental temperatures. However, the ... -
Pre-clinical development of NOX2/ROS blood-based biomarker of TBI
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)There is an urgent need to develop predictive biomarkers for traumatic brain injury (TBI) to aid clinical diagnosis and treatment of head injury patients. NADPH oxidase 2 (NOX2) activity and oxidized biomarkers are being ... -
Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ... -
Single cell analysis of iNKT cell heterogeneity, phenotype, and function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ... -
The role of tissue-resident memory T cells in immunity to Bordetella pertussis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Whooping cough (pertussis) is a severe respiratory disease cause by the Gram-negative bacterium Bordetella pertussis. Despite high vaccine coverage, a resurgence of pertussis has been observed over recent years. Although ... -
Tumour derived microRNA-21 reprograms macrophage responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)The role of the oncogenic yet anti-inflammatory microRNA-21 (miR-21) in the tumour microenvironment (TME) is not clearly defined, despite its upregulation in many cancers. Since re-education of macrophages by tumour derived ... -
Re-evaluating the Role of SARM1 as a Transcriptional Regulator Using Improved Genome-Edited Mouse Models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)SARM1 is an ancient and highly conserved protein, initially described as having functions in innate immunity. In the last decade, our understanding of SARM1 structure and function expanded rapidly. The majority of research ... -
EVOLUTIONARY PRINCIPLES IN HUMAN CANCER IMMUNOLOGY
The immune system plays a fundamental role in driving the evolution of malignant cells. The anti-tumour immune response removes immunogenic tumour cells and preserves immune evasive cells. A clinically detectable tumour ...
