Browsing Biochemistry (Scholarly Publications) by Sponsor "Health Research Board (HRB)"
Now showing items 21-25 of 25
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Preparation of Pre-Confluent Retinal Cells Increases Graft Viability In Vitro and In Vivo: A Mouse Model
(2011)Purpose: Graft failure remains an obstacle to experimental subretinal cell transplantation. A key step is preparing a viable graft, as high levels of necrosis and apoptosis increase the risk of graft failure. Retinal ... -
Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV
(2011)The nucleoside analogue Ribavirin significantly increases patient response to IFN-? treatment of HCV, by directly inhibiting viral replication. Recent studies indicate that Ribavirin also regulates immunity and we propose ... -
The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10.
(2014)MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukaemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role ... -
SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?
(Springer, 2016-03-24)Since their discovery, SOCS have been characterised as regulatory cornerstones of intracellular signalling. While classically controlling the JAK/STAT pathway, their inhibitory effects are documented across several ... -
A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs) acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is ...