School of Chemistry: Recent submissions
Now showing items 141-160 of 1366
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Alcohol Pre-treatment to Eliminate the Interference of Micro Additive Particles in the Identification of Microplastics Using Raman Spectroscopy
(2022)Raman spectroscopy is an indispensable tool in the analysis of microplastics smaller than 20 μm. However, due to its limitation, Raman spectroscopy may be incapable of effectively distinguishing microplastics from micro ... -
Restructuring of emergent grain boundaries at free surfaces – An interplay between core stabilization and elastic stress generation
(2022)Emergent grain boundaries at free surface impact a wide range of material properties but little is known about their atomic-scale behavior. Using scanning tunneling microscopy and calculations, we studied the structure of ... -
Electrochemical Detection of Isolated Nanoscale Defects in 2D Transition Metal Dichalcogenides
(2022)We show that nanometer and sub-nanometer scale defects in two-dimensional transition metal dichalcogenides can be detected electrochemically using scanning electrochemical cell microscopy (SECCM). We detect isolated anomalous ... -
On the Synthesis and Utilization of geminal-Dimethyl Hydroporphyrins and Tetraphenylethylenes in Photodynamic Therapy
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Chapter 1 introduces the main concepts of this thesis: photodynamic therapy (PDT), chlorins and photosensitizer arrays. In the case of PDT multiple topics are discussed, namely, the qualities of an ideal photosensitizer, ... -
Unravelling the Pivotal Role of Atropisomerism for Cellular Internalization
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Atropisomerism presents an intriguing, often neglected, source of varied biological activity in drug development. For a stable atropisomeric drug mixture, assessment of individual atropisomers may reveal an individual ... -
Development of modified nucleosides for targeting the DNA repair enzyme SNM1A
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand ... -
Triplet Photosensitisers: From Molecular Designto Light-Driven Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Transition metal complexes, particularly Ir(III) and Ru(II), exhibit attractive photophysical properties and have long been the subject of scientific research owing to their use in various light-driven applications. This ... -
Selective Deposition: Fabrication of Coherent Nano-Dimensioned Metal Oxide Films by Monolayer Polymer Brush Template Assisted Inclusion
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022) -
Synthesis and Physicochemical Characterisation of Pristine Metal-Organic Frameworks, Thin-Films and Derived Materials
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Metal-organic frameworks (MOFs) are hybrid coordination materials, characterised by their high surface area and internal porosity, formed from organic linkers and inorganic nodes. Additionally, MOFs have the ability to act ... -
Porphyrin Atropisomerism - a New Twist in Molecular Recognition and Supramolecular Architectures
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The unifying theme of the work reported in this thesis is the exploitation of the flexibility of the porphyrin macrocycle using sterically demanding units to construct supramolecular receptors for selective guest encapsulations. ... -
Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Photodynamic therapy (PDT) is an anti-cancer treatment method which uses the combined effect of a photosensitizing drug, light, and oxygen to cause selective damage to target tissue. The second generation photosensitizer ... -
Development of Supramolecular Coordination Materials Using Naphthalimide and 2,6-bis(triazol-4-yl)pyridine Motifs
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Structural coordination chemistry can be ultilised to develop functional supramolecular materials such as coordination polymers, soft materials, and metal organic frameworks. By applying the principles of self-assembly an ... -
Computational Modelling of Perovskite-based Materials for Solid Oxide Fuel Cell Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The development and use of clean and renewable modes of power generation is essential to address the increasing environmental and health concerns associated with fossil fuel consumption. Solid oxide fuel cells (SOFCs) ... -
Development and Studies of New Magnetic Core@Shell Nanostructures
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)In this work, the synthesis of various magnetic nanoparticles such as magnetite, manganese ferrite, cobalt ferrite and copper ferrite is explored using different synthetic protocols. The produced nanomaterials are characterised ... -
Development of 2D Nanomaterials Based Membranes for Nanofiltration Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The main aim of this work was to develop new membranes based on 2D nanomaterials, such as boron nitride (BN) and molybdenum disulphide (MoS2) for potential nanofiltration applications. The exfoliation and membrane preparation ... -
Selective Mineralisation by Hydrothermal Methods
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)The use of hydrothermal synthesis has led to the control of the size and shape of various materials of inorganic nature. It has also been highlighted as a green, cheap, and reliable synthetic method, by using water in ... -
Nanostructured carbon-based materials as sustainable electrocatalysts for energy conversion applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Electrochemistry has recently gained increased attention as a versatile strategy for achieving challenging transformations at the forefront of organic chemistry. Electrochemistry’s unique ability to generate highly ... -
De-novo designed ??-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P
(2022)An investigation into the effect of modified β-lysines on the growth rates of eubacterial cells is reported. It is shown that the effects observed are due to the post translational modification of Elongation Factor P (EFP) ... -
Naphthalimides Exhibiting Aggregation-Induced Emission for Bioimaging Applications
In this project, a 1,8-naphthalimide (Nap, compound 8) is functionalised with two triphenylamino (TPA) moieties which, by virtue of having multiple freely rotating aromatic rings, are capable of exhibiting aggregation-induced ... -
Generation and Reactivity of Late Transition Metal Hydr(oxo) Complexes Supported by Tripodal Carboxamidate Ligand
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Metal oxo complexes (M=O) are important mediators of oxidative transformations in biological systems.1 Their high reactivity and transient nature have limited their study, with only a handful of well characterized oxo ...
