Mechanical & Manufacturing Eng (Theses and Dissertations): Recent submissions
Now showing items 41-60 of 244
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A biomechanical analysis of cyclist collisions in Ireland
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)As both a mode of transport and recreational activity, cycling has well-known health, environmental, and economic benefits. For these reasons, it has been encouraged in many countries, including the Republic of Ireland. ... -
Optimisation and 3D Printing of Paediatric Stents
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Aortic coarctation is a congenital heart defect that occurs 3 per 10,000 live births with a life expectancy of 35 years if left untreated. Stenting is a common treatment method, but devices are not specifically designed ... -
Non-Invasive metabolic profiling in tissue engineering and innate immunology by 2P-FLIM
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)During the golden age of biochemistry from 1920s to 1960s, many of the metabolic pathways responsible for nutrient usage and energy production in humans and other organisms was defined. During this period, glycolysis, Krebs ... -
Development of an off-the-shelf biomimetic vascular graft for small diameter vascular regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Cardiovascular disease is one of the leading causes of death worldwide. The impairment of blood flow can require a total vessel substitution, but current grafts fail to recapitulate the unique mechanical behavior of native ... -
Applying thermal post-processing techniques to engineer the microstructure and mechanical performanceof selective-laser-melted Ti-6Al-4V ELI
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)As an additive manufacturing technology, selective laser melting (SLM) affords the creation of customisable parts at high resolutions to within the micron range. Among the materials being processed by SLM systems, the ... -
Grasping Moving Objects: Adaptive Motion Through Tactile Sensing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)The aim of this project is to explore how adaptive grasping motions, informed by real-time tactile feedback, can improve grasp robustness when grasping moving objects. It was hypothesised that an adaptive grasping motion, ... -
An investigation into diffusion tensor imaging-derived metrics in arterial tissue as biomarkers for disease progression, plaque rupture and graft recellularisation
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Non-invasive imaging offers great potential for several clinical applications, both in disease and treatment monitoring. Specifically, within vascular tissue better clinical indicators for vulnerable atherosclerotic plaque, ... -
Empirical evaluation of electrochemical air pollution sensors
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)The objective of the research was to characterise the potential of state-of-the-art low cost gas air pollution sensors to measure air pollution levels in an active urban environment, through the implementation of a set of ... -
Investigating Failure Mechanisms, Defect Tolerance and Repair of Plant Stems for Practical Applications
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Plants are complex in their biological composition and can provide inspiration for man-made engineering products. Designing bio-inspired products involves understanding the intricacies of plants? mechanical properties and ... -
Electroconductive Biomaterial Platforms: from Piezoresistive Sensors to Cardiac Tissue Engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)New classes of functional materials and the rapid advances being made in manufacturing technologies are key requirements to drive the next step forward in healthcare. In recent decades, conjugated polymers have gained ... -
Modelling techniques to inform the design of sub-wavelength periodic acoustic structures
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Minimising the environmental impact of aircraft noise and ensuring the sustainability of air travel in the future is crucial for the development of the industry. The ad- vancement in additive manufacturing paves the way ... -
3D Bioprinted Cartilaginous Templates as Developmentally Inspired Implants for Large Bone Defect Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Whilst bone possesses an inherent capacity for regeneration, defects above a critical size cannot heal on their own. Damaged or diseased bone can be treated using autografts or a range of different bone grafting biomaterials, ... -
The role of the biophysical cues on the initiation, progression and maintenance of a chondrogenic phenotype in human stem cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Articular Cartilage Tissue Engineering (AC TE) is a promising strategy for the treatment of small cartilage defects, however complete mimicry of the native tissue remains a significant challenge. Mechanical cues like dynamic ... -
Fundamental insights into the biomechanics of atherosclerotic plaque tissue: Determining possible new diagnostic measures of plaque vulnerability
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Carotid atherosclerotic plaque rupture is known to be a major contributor to ischaemic stroke cases. The development of atherosclerotic plaques within the vessel wall alters both the geometry and mechanical environment of ... -
Development and Functional Assessment of a Decellularised Injectable Biomaterial Combined with Nasal Chondrocytes for Intervertebral Disc Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Lower Back Pain (LBP) is known to be a major health issue worldwide with a significant socioeconomic impact and it is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD). IVD degeneration ... -
Density Optimisation & In-Situ Microstructure Decomposition of As-Built Selective Laser Melted Ti-6Al-4V
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Additive manufacturing of titanium provides many advantages over traditional methodologies such as the ability to produce complex parts at no additional cost. One such AM method, selective laser melting (SLM) is a powder ... -
Directional Solidification Experiments with the Transparent Model Alloy Neopentyl Glycol-35wt.%(D)Camphor
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)This thesis describes the development of an experimental facility in combination with image processing and computer vision techniques for the visualisation and characterisation of dendritic growth structures in the transparent ... -
BIOFABRICATION STRATEGIES TO GUIDE THE SELF-ORGANISATION OF BIOMIMETIC CARTILAGE AND OSTEOCHONDRAL TISSUES
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure, composition and functional properties of the target tissue. This has ... -
Developing Microphysiological Systems of Bone Development, Physiology, and Repair
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Accurate models of human tissues and organ systems are foundational in our efforts to better understand human physiology. In the context of bone, a number of in vitro and in vivo models have been developed that facilitate ... -
Development of localised process parameter control for repeatability in metal additive manufacturing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Due to the many advantages associated with metal additive manufacturing (AM) processes, research into these technologies has grown significantly over recent years. However, repeatability and reproducibility are critical ...
