Mechanical & Manufacturing Eng (Theses and Dissertations): Recent submissions
Now showing items 61-80 of 244
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Numerical assessment of the performance of a wastewater pump under off-design operating conditions
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Pumps are often key elements of industrial processes, and are commonly used to move water in municipal water schemes and in wastewater treatment of industrial effluents, representing a substantial energy cost. In the ... -
Influence of Mechanical Environment on Limbal and Corneal Epithelial Cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Corneal blindness is the 4th leading cause of blindness and the most transplanted tissue worldwide. Severe donor shortages and immune rejection has led to research into alternative therapies for corneal transplantation. ... -
Investigation into the collagen fibre-mediated fatigue mechanics of bovine pericardium for use in bioprosthetic heart valves
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Bioprosthetic heart valve replacements have long been associated with inadequate durability in vivo, owing primarily to mechanical damage and calcification of the glutaraldehyde-fixed bovine pericardial leaflets (GLBP). ... -
Development of a performance framework to support the innovation process
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Performance frameworks (PFs) for measuring the innovation process are critical for both research and practice. However, existing PFs neglect performance indicators (PIs) and dimensions relevant to companies' current ... -
Ultrasonic impact grinding machine tool and process development
(University of Dublin, Trinity College, 2013)Ultrasonic Impact Grinding (UIG) is a mechanical material removal process used to erode holes and cavities in hard and brittle materials such as glass, ceramics, silicon carbide, quartz and ... -
Characterization of the Erosion of Soft Tissue by Surgical Mesh In Vitro
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Surgical mesh implants have been extensively used in hernia treatment and pelvic organ procedures, such as organ prolapse and stress urinary incontinence. Since the onset of the use of such implants, major complications ... -
On-site energy generation for a decarbonized Irish manufacturing industry
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)The objective of the thesis is to explore whether it is technically, economically and en-vironmentally feasible for an Irish manufacturing facility to become an energy prosumer, byproducing energy on-site, and decrease the ... -
Proxy measurement and strategic metering methodologies for resource transparency of industrial systems
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)For the latest advancement of manufacturing systems, namely Industry 4.0 or Smart Manufacturing, large amounts of precise process data are required. However, the acquisition of sufficient data represents a challenge for ... -
The development of biomimetic scaffolds for osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC cause pain, impaired mobility and can develop to osteoarthritis (OA), a disease affecting millions of adults ... -
Development and characterization of corneal substitutes from decellularized tissues
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Diseases affecting the cornea can lead to vision impairment and ultimately to blindness. It is estimated that 45 million people worldwide suffer from corneal blindness. Rejection in high-risk patients and donor shortage ... -
Objective and Quantitative acoustic-analysis of musicians dystonia
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Musician s Dystonia (MD) is the most common movement disorder affecting musicians. Being a specific phenotype of Dystonia, MD is a focal, task-specific and painless disorder that affects motor control during musical ... -
3D bioprinting of cartilage-mimetic implants for biological joint resurfacing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects and ultimately regenerating whole osteoarthritic ... -
The Development of a Novel 3D Bioprinting Strategy to Drive Vascularisation, and its Application for Bone Tissue Engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the major challenges facing the field of tissue engineering today is vascularisation. Without a system in place to circulate oxygen, nutrients and metabolites, the size of many tissue engineered constructs is ... -
Adaptive Liquid Cooling Methods in Microchannel Heat Sinks
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)This work investigates the effect of implementing three varying cooling techniques for high heat flux electronics cooling. High heat fluxes are being experienced in data centres as the number of transistors per inch increases ... -
Design and optimisation of focused infrared heating devices
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020) -
Pedestrian whole body ground contact mechanisms and head injury assessment following vehicle impact
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)According to the WHO, there are an estimated 1.35 million road-traffic related deaths each year, with pedestrians constituting approximately 22% of this figure, which justifies the necessity of research into vehicle-pedestrian ... -
Multipotent vascular stem cells and the effects of cyclic tensile strain, collagen structure and stenting on medial vascular cell populations
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Atherosclerosis is one of the leading causes of mortality worldwide, and presents as a narrowing or occlusion of an artery. Interventions to re-open the arterial lumen can result in re-occlusion through intimal hyperplasia. ... -
On effect of primed cellular microcapsules and pH neutralizing biomaterials to augment regeneration of the intervertebral disc
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the most common topics of research worldwide for medical health care is low back pain (LBP). It is widely accepted that LBP is associated with degeneration of the intervertebral disc (IVD), the shock absorbent soft ... -
Unravelling the role of mechanical cues on the chondrogenic differentiation of stem cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)The inability of adult articular cartilage to regenerate has motivated the development of tissue engineering strategies to repair cartilage defects before they progress to osteoarthritis. Common cell based strategies ... -
Micromechanical modelling of normal, drug treated and osteoporotic bone using scanning acoustic microsopy and finite element analysis
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)Ultrasonic methods were exclusively used to image cortical bone at high resolutions. A scanning acoustic microscope was used at a frequency of 150 MHz giving a resolution of 20μm. Images were taken of ovine bone samples ...
