Mechanical & Manufacturing Eng (Scholarly Publications): Recent submissions
Now showing items 521-540 of 700
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The anisotropic mechanical behaviour of passive skeletal muscle tissue subjected to large tensile strain
(2013)The passive mechanical properties of muscle tissue are important for many biomechanics applications. However, significant gaps remain in our understanding of the three-dimensional tensile response of passive skeletal ... -
Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad.
(2014)The objective of this study was to investigate how joint specific biomechanical loading influences the functional development and phenotypic stability of cartilage grafts engineered in vitro using stem/progenitor cells ... -
Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus - Effect of TGF-β3 supplementation and oxygen culture conditions
(2014)Disc herniation as a result of degenerative or traumatic injury is believed to be the primary instigator of low back pain. At present there is a lack of viable treatment options to repair damaged annulus fibrosus tissue ... -
Mechanical behaviour of transparent nano fibrillar cellulose-chitosan nano composite films in dry and wet conditions
(2014)Transparent, biocompatible and biodegradable chitosan (CS) nanocomposite films rein- forced with nanofibrillar cellulose (NFC) were prepared by solution casting. The effects of NFC content on the mechanical properties in ... -
Comparison of metrics for the evaluation of similarity in acoustic pressure signals
(2013)Determining if aeroacoustic sound predictions are accurate is di cult because the question of how to de ne `accurate' remains open. This communication evaluates four metrics for comparing time-domain pressure signals, ... -
Vortex shedding from a wind turbine blade section at high angles of attack
(2013)The unsteady flow around a stationary two-dimensional wind turbine blade section (NREL S809) has been simulated using unsteady RANS with the SST turbulence model at Re = 106 and high angles of attack. Vortex shedding ... -
A new model for damping controlled fluidelastic instability in heat exchanger tube arrays
(2009)Heat exchnager tube arrays are susceptible to damage due to flow-induced vibration, with fluidelastic instability the potnetially the most destructive mechanism. In this paper a simple wake model consisting of a convecting ... -
A practical approach to parameter identification for a lightly damped, weakly nonlinear system
(Elsevier, 2008)Fluidelastic systems are often lightly damped and exhibit weak non-linear damping. The weak linear and non-linear damping forces have a significant effect on the long term behaviour of the system. However, parameter ... -
Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression
(2013)The objective of this study was to explore how the response of mesenchymal stem cells (MSCs) to dynamic compression (DC) depends on their pericellular environment and the development of their cytoskeleton. MSCs were first ... -
Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells
(2013)The objective of this study was to identify a combination of growth factors that could be used with hydrostatic pressure (HP) stimulation to enhance the functional development of cartilaginous grafts engineered using human ... -
Aeroacoustic source characterization technique applied to a cylindrical Helmholtz resonator
(2011)The aim of this work is to investigate the sound produced by a Helmholtz resonator excited by a boundary layer. A deep cylindrical cavity with a small rectangular opening was designed to allow Helmholtz resonance as well ... -
Recapitulating Aspects of the Oxygen and Substrate Environment of the Damaged Joint Milieu for Stem Cell-Based Cartilage Tissue Engineering.
(2013)Human infrapatellar fat pad contains a source of mesenchymal stem cells (FPSCs) that potentially offer a novel population for the treatment of damaged or diseased articular cartilage. Existing cartilage repair strategies ... -
Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells.
(2012)Hydrostatic pressure (HP) is a key component of the in vivo joint environment and has been shown to enhance chondrogenesis of stem cells. The objective of this study was to investigate the interaction between HP and ... -
Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: a mechanobiological model.
(2012)Extrinsic mechanical signals have been implicated as key regulators of mesenchymal stem cell (MSC) differentiation. It has been possible to test different hypotheses for mechano-regulated MSC differentiation by attempting ... -
The role of the superficial region in determining the dynamic properties of articular cartilage.
(2012)OBJECTIVE: The objective of this study was to elucidate the role of the superficial region of articular cartilage in determining the dynamic properties of the tissue. It is hypothesised that removal of the superficial ... -
European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate.
(2012)The aim of this study was to explore how cell-matrix interactions and extrinsic mechanical signals interact to determine stem cell fate in response to transforming growth factor-?3 (TGF-?3). Bone marrow derived mesenchymal ... -
The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad-derived stem cells.
(2012)Engineering functional cartilaginous grafts using stem cells isolated from osteoarthritic human tissue is of fundamental importance if autologous tissue engineering strategies are to be used in the treatment of diseased ... -
The influence of construct scale on the composition and functional properties of cartilaginous tissues engineered using bone marrow-derived mesenchymal stem cells.
(2012)Engineering cartilaginous tissue of a scale necessary to treat defects observed clinically is a well-documented challenge in the field of cartilage tissue engineering. The objective of this study was to determine how the ...
