Browsing Genetics (Theses and Dissertations) by Sponsor "Irish Research Council"
Now showing items 1-3 of 3
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Exploration of gene therapies targeting oxidative stress and NAD+ pathways for the treatment of optic neuropathy
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The World Health Organisation estimates that there are approximately 300 million people suffering from some form of blindness, from inherited retinal degenerations to complex diseases such as glaucoma. The vast heterogeneity ... -
The inner Blood-Retina Barrier in Age-related Macular Degeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness in aged populations worldwide. AMD involves the gradual deterioration of central retinal vision overtime but the exact pathobiological mechanisms are ... -
Understanding the role of Polycomb-like proteins in cellular quiescence and cancer
Polycomb proteins are a class of chromatin modifying complexes that are essential regulators of development, differentiation and maintenance of cell lineage. Polycomb proteins exist in two large, distinct, multimeric ...
