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Biology Teaching Centre
Biology Teaching Centre -
Genetics
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Microbiology
Recent Submissions
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Causes and consequences of large-scale copy number alterations in cancer evolution
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Cancer genomes are characterised by genomic instability and frequent large-scale copy number alterations across the genome. The aim of this thesis was to investigate the consequences of these alterations from an evolutionary ... -
Investigating the effects of H3K27M on PRC1 in Diffuse Midline Glioma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Diffuse midline glioma (DMG) is a universally lethal paediatric brain tumour characterised by a mutation in histone H3 (H3K27M). This mutation leads to a global reduction in the repressive histone modification H3K27me3. ... -
Understanding how community context drives virulence-associated traits in the Cystic Fibrosis pathogen Pseudomonas aeruginosa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)The lungs of patients with Cystic Fibrosis (CF) are often chronically colonised by a plethora of microbial species, including the major CF pathogen Pseudomonas aeruginosa (P. aeruginosa). Herewith, when examining ... -
Investigating the Impact of Anthropogenic Change on Soil Microbiome Functioning and Crop Health
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)Anthropogenic change poses significant challenges for society today. Soil microbial communities are under constant anthropogenic stress from pollution, rising climates, pesticide use, and deforestation to name a few. We ... -
Stories spun in DNA: Unravelling the fine-scale genomics of ancient Scotland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, School of Genetics and Microbiology, 2025)The growing field of ancient genomics has revealed the broad genomic changes associated with major archaeological horizons in past Britain and Ireland. It has been established that genomic continuity exists between the ... -
Inner Blood Retinal Barrier integrity in the pathogenesis of Retinitis Pigmentosa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Retinitis Pigmentosa (RP) is the most prevalent form of Inherited Retinal Degeneration, estimated to impact 1 in 4000 people across Ireland. The disease is characterized by enhanced genetic complexity which restricts the ... -
The inner Blood-Retina Barrier in Age-related Macular Degeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness in aged populations worldwide. AMD involves the gradual deterioration of central retinal vision overtime but the exact pathobiological mechanisms are ... -
An Investigation of Regulatory and Chromatin Drivers of Cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Chromatin and its regulatory elements are crucial for controlling gene expression and maintaining cellular identity. Chromatin, a dynamic structure made of DNA and histone proteins, is organized into nucleosomes. Modifications ... -
Ancient genomics and the origin, dispersal, and development of domestic sheep
(2025)The origins and prehistory of domestic sheep (Ovis aries) are incompletely understood; to address this we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Genomes from Central ... -
Characterising the small RNA-regulatory architecture of Acinetobacter baumannii
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)The Gram-negative bacterium Acinetobacter baumannii is a significant opportunistic pathogen in critically ill and hospitalised patients. It exhibits a remarkable ability to survive under harsh environmental conditions, ... -
Characterisation of the alternative sigma factor SigAB in Acinetobacter baumannii
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Acinetobacter baumannii is a priority pathogen and is known to be a leading cause of nosocomial infections worldwide. It is associated with a variety of illnesses including septicaemia, pneumonia, and urinary tract ... -
Molecular Control of Cell Stress-initiated Inflammation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Inflammation is the cornerstone of homeostasis. At one end of the spectrum, inflammation is activated by severe disturbances to homeostasis, typically as a result of infection or injury. Inflammation in this context is ... -
Molecular characterisation of tagO-deficient mutants of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Wall teichoic acid (W TA) is a major component of the Gram -positive bacterial cell wall. Despite not being essential, it plays important roles in cell growth, division, morphology and virulence. The enzyme TagO initiates ... -
An investigation of LytE in fulfilling the D,L-endopeptidase requirement for viability of Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The bacterial cell wall determines cell shape, resists turgor pressure, provides a microclimate between the cell and the external milieu and acts as a platform for the exposure of cellular proteins. The cell wall is a ... -
Neurophysiological changes associated with olfactory short-term habituation in Drosophilia melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The term habituation describes a simple form of learning that is characterized by a behavioural response decrement following repeated or prolonged sensory stimulation (Christoffersen, 1997; Rankin et al, 2009; Thompson and ... -
Exploring the function of SUPERMAN, and the repression of the trichome initiation pathway, during Arabidopsis flower development
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The notion that flowers are in essence modified leaves was hypothesized as far back as 1790. Supporting this early hypothesis, genetic analyses of floral organ identity genes in the model plant Arahidopsis thaliana showed ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The objectives of this study were (i) to establish the mechanism by which the PhoPR TCS is activated and deactivated in Bacillus subtilis subsp subtilis (strain 168) and subsp spizizenii (strain W23) and (ii) to determine ... -
Analysis of the mechanism of protein A release and its contribution to immune evasion by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2016)The immunoglobulin binding protein A (SpA) of Staphylococcus aureus was one of the first cell wall-associated proteins of Gram-positive bacteria to be identified and characterised. It is synthesized as a precursor with a ... -
A history of multiple Denisovan introgression events in modern humans
(2024)The identification of a new hominin group in the Altai mountains called Denisovans was one of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal remains, the Denisovan fossil record ... -
Population genetics of Ancient Western Europe
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The field of Ancient DNA has been the subject of significant progress during the last decade, shifting from the analysis of a few hundred basepairs to whole-genome data. The main advantage of ancient DNA is the direct ...
