Genetics (Theses and Dissertations): Recent submissions
Now showing items 1-20 of 218
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Evolution of Tissue-specific Expression Following Teleost and Salmonid Whole-Genome Duplication
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)This thesis investigates the evolutionary consequences of two whole-genome duplication (WGD) events in ray-finned fish, the Teleost Genome Duplication (TGD) and the Salmonid-Specific Genome Duplication (Ss4R), through ... -
Causes and consequences of large-scale copy number alterations in cancer evolution
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Cancer genomes are characterised by genomic instability and frequent large-scale copy number alterations across the genome. The aim of this thesis was to investigate the consequences of these alterations from an evolutionary ... -
Investigating the effects of H3K27M on PRC1 in Diffuse Midline Glioma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Diffuse midline glioma (DMG) is a universally lethal paediatric brain tumour characterised by a mutation in histone H3 (H3K27M). This mutation leads to a global reduction in the repressive histone modification H3K27me3. ... -
Stories spun in DNA: Unravelling the fine-scale genomics of ancient Scotland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, School of Genetics and Microbiology, 2025)The growing field of ancient genomics has revealed the broad genomic changes associated with major archaeological horizons in past Britain and Ireland. It has been established that genomic continuity exists between the ... -
Inner Blood Retinal Barrier integrity in the pathogenesis of Retinitis Pigmentosa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Retinitis Pigmentosa (RP) is the most prevalent form of Inherited Retinal Degeneration, estimated to impact 1 in 4000 people across Ireland. The disease is characterized by enhanced genetic complexity which restricts the ... -
The inner Blood-Retina Barrier in Age-related Macular Degeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness in aged populations worldwide. AMD involves the gradual deterioration of central retinal vision overtime but the exact pathobiological mechanisms are ... -
An Investigation of Regulatory and Chromatin Drivers of Cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Chromatin and its regulatory elements are crucial for controlling gene expression and maintaining cellular identity. Chromatin, a dynamic structure made of DNA and histone proteins, is organized into nucleosomes. Modifications ... -
Molecular Control of Cell Stress-initiated Inflammation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Inflammation is the cornerstone of homeostasis. At one end of the spectrum, inflammation is activated by severe disturbances to homeostasis, typically as a result of infection or injury. Inflammation in this context is ... -
An investigation of LytE in fulfilling the D,L-endopeptidase requirement for viability of Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The bacterial cell wall determines cell shape, resists turgor pressure, provides a microclimate between the cell and the external milieu and acts as a platform for the exposure of cellular proteins. The cell wall is a ... -
Neurophysiological changes associated with olfactory short-term habituation in Drosophilia melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The term habituation describes a simple form of learning that is characterized by a behavioural response decrement following repeated or prolonged sensory stimulation (Christoffersen, 1997; Rankin et al, 2009; Thompson and ... -
Exploring the function of SUPERMAN, and the repression of the trichome initiation pathway, during Arabidopsis flower development
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The notion that flowers are in essence modified leaves was hypothesized as far back as 1790. Supporting this early hypothesis, genetic analyses of floral organ identity genes in the model plant Arahidopsis thaliana showed ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The objectives of this study were (i) to establish the mechanism by which the PhoPR TCS is activated and deactivated in Bacillus subtilis subsp subtilis (strain 168) and subsp spizizenii (strain W23) and (ii) to determine ... -
Population genetics of Ancient Western Europe
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The field of Ancient DNA has been the subject of significant progress during the last decade, shifting from the analysis of a few hundred basepairs to whole-genome data. The main advantage of ancient DNA is the direct ... -
Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arahidopsis thaliana has led to the proposal of the ABC model of ... -
Genomic and transcriptomic profiling of Coeliac Disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Coeliac Disease (CD) is a chronic immune mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Genome-wide association studies (GWAS) have ... -
Neutrophil-derived proteases act as global regulators of IL-1 family cytokine activation states
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)IL-1 family cytokines are pleiotropic cytokines capable of eliciting robust proinflammatory cytokine and chemokine secretion from a broad variety of cell types and tissues. Recent evidence has strongly implicated IL-36 ... -
The ophthalmic manifestations of neurological disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)The retina is responsible for visual processing by converting light signals into nerve impulses. It comprises both the central retina, termed the macula, and the peripheral retina. There are several subtypes of peripheral ... -
Characterisation of the floral transcriptome of Sinapis alba and analysis of PRC2 accessory proteins in Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Flower development has been studied in the model organism Arabidopsis thaliana for decades. Years of research into the development of the floral organs - carpels, stamens, petals and sepals - led to the formation of the ... -
Investigating the recruitment, interactions, and activity of Polycomb proteins in development and disease.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Polycomb group proteins are chromatin regulators associated with transcriptional repression of developmentally important genes. They assemble into multiprotein complexes, including Polycomb Repressive Complex 1 (PRC1) and ... -
Investigating the roles of the floral-associated genes TRIPTYCHON, SHATTERPROOF and AGAMOUS in Arabidopsis thaliana and Brassica rapa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)The genetic mechanisms responsible for flower development has been studied for over four decades now in Arabidopsis thaliana, a model organism for plants. However, more recently, plant research has become increasingly ...
