School of Biochemistry & Immunology: Recent submissions
Now showing items 261-280 of 1067
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CRISPR Gene Editing Approaches in the Study of Allergy and Infertility
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019) -
Structural aspects of the regulation of Parkinson's Disease-associated LRRK2 Kinase by Rab GTPases
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)The Rab family of small GTPases are the premier organisers of endocytic and secretory pathways in cells. They behave as molecular 'on/off' switches and in their active GTP-bound state recruit soluble effector proteins to ... -
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
(2018)Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of ... -
Evidence against a role for NLRP3-driven islet inflammation in db/db mice
(2018)Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure ... -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses
(2019)Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of a Helicobacter ... -
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
(2019)These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme ... -
Analysis of the role of Krebs cycle rewiring in macrophage cytokine production
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways ... -
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
(2019)Astrocytes are the most numerous cell type in the brain and perform several essential functions in supporting neuronal metabolism and actively participating in neural circuit and behavioral function. They also have ... -
Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
(2018)Invariant natural killer T (iNKT) cells recognize glycolipid antigens bound to CD1d molecules on antigen-presenting cells. Therapeutic activation of iNKT cells with the xenogeneic glycolipid α-galactosylceramide (α-GalCer) ... -
An investigation into the role of TLR4 interactor with leucine rich repeats (TRIL) in Toll-like receptor responses in brain
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)TLR4 interactor with leucine rich repeats (TRIL) was originally described as a protein required for Toll-like receptor 4 (TLR4) signalling. This thesis provides new insights into the function of TRIL within TLR signalling ... -
Distinct local and systemic innate immune gene expression in response to Staphylococcus aureus-induced subclinical mastitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Both local and systemic innate immune activity has a critical role in maintaining immunological homeostasis in the mammary gland. Dysregulation of the homeostatic process leads to increased infection and related pathology, ... -
The Queuine-Transfer RNA Pathway as a novel drug mechanism to treat Multiple Sclerosis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Queuine is a pyrrolopyrimidine molecule that is irreversibly incorporated into the anticodon loop of transfer RNA (tRNA) for the amino acids Asparagine, Aspartate, Tyrosine and Histidine. Only bacteria synthesize queuine, ... -
Immunomodulatory properties of endogenous danger signals
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The 'danger model' proposes that dying cells release specific endogenous molecules into the extracellular milieu following loss of plasma membrane integrity. This model postulates that these endogenous molecules, referred ... -
A structural study of ALgE, transporter of alginate from Pseudomonas aeruginosa PAOI
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious diseases in humans with immune system deficiencies, such as cystic fibrosis, wound infections, urinary tract infections, and blood stream ... -
Structural and functional studies of a turmour killing protein-fatty acid complex
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)HAMLET (Human Alpha-lactalbumin Made LEthal to Tumour cells) is a complex between the milk protein a-lactalbumin (a-LA) and a fatty acid, oleic acid (OA), and displays remarkable properties of selectively killing tumour ... -
Immunomodulatory activity of products from the helminth parasite Fasciola hepatica
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Helminths have evolved strategies to evade host immune responses and these have been shown to be associated with simultaneous subversion of immune responses towards bystander antigens. This phenomenon forms the basis of ... -
Delineating molecular mechanisms of inflammation-induced delirium using a novel mouse model
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Delirium is a syndrome of acute and transient confusion with disruption of attention and cognition; it is a common but underdiagnosed neuropsychiatric condition, which is predictive of increased fimctional decline, dementia ... -
Modulation of microRNA by toll-like receptors
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Toll-like receptors (TLRs) play a key role regulating gene expression following the detection of a pathogen by cells to bring about an inflammatory response. I investigated whether or not activation of TLRs in dendritic ... -
Characterisation of the innate immune response to Campylobacter jejuni colonisation in the chicken intestine
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Campylobacter jejuni is the leading cause of gastroenteritis in humans, and chickens are the primary vector for infection. The microbe colonises the caeca of birds as a commensal, and it is hypothesised that intestinal ...
