School of Biochemistry & Immunology: Recent submissions
Now showing items 301-320 of 1067
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The immunodulatory effects of the cAMP effector Epac
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Cyclic AMP is an extremely important second messenger and is known to be a central mediator of inflammation and regulator of the immune response. For many years it was thought that the effects of cAMP on immunity were ... -
Mal is not esential for TLR2 signalling and inhibits signalling by TLR3
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)This thesis set out to systematically analyse the role of Mai in signalling by TLR2, TLR3 and TLR4 in murine macrophages and dendritic cells. It has revealed that Mai is not essential to TLR2 signal transduction, is required ... -
Interferon lambda, dendritic cells and Hepatitis C virus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)It is estimated that ~3% of the world's population is infected with Hepatitis C virus (HCV), a hepatotropic virus which can lead to liver fibrosis, cirrhosis and hepatocellular carcinoma. Of those infected, ~20% clear the ... -
The role of microRNA-107 in Toll-like receptor signaling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)MicroRNAs (miRNAs) are a novel class of small non-coding RNA regulatory molecules which post-transcriptionally regulate genes in a fine-tuning manner. Multiple miRNAs have been shown to be regulated by Toll-like receptors ... -
Identification of the components of the eukaryotic queuine transglycosylase complex and the effect of its substrate queuine on metabolism
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Queuine is a 7-deazaguanine derivative of guanine, which replaces guanine in position 34 of the anticodon loop of the transfer RNA for the amino acids, asparagine, aspartic acid, histidine and tyrosine. This base or related ... -
Mechanistic and functional studies on biliverdin IXa reductase from the cyanobacterium synechocystis sp.PCC6803
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The enzymes of heme metabolism and phycobilin biosynthesis in the cyanobacterium Synechocystis sp. PCC6803, along with their reducing partners, ferredoxin and ferredoxin reductase were produced through recombinant DNA ... -
Exploring an immune function for murine SARM
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Innate immune cells, such as tissue-residing macrophages and dendritic cells (DCs) play a key role in initiating an immune response following the detection of invading pathogens via germline-encoded pattern-recognition ... -
GlcNAc transferases and glycoengineering in Chinese hamster ovary cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Glycosylation constitutes one of the most important post-translational modifications of proteins, with over 60% of proteins known to be glycosylated. GlcNAc transferases (GnTs) belong to a large subfamily of glycosyltransferases ... -
Cancer cell bioenergetics in response to anti-cancer agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Altered metabolism is a hallmark of cancer (Hanahan and Weinberg, 2011) and while genetic and molecular modifications have enabled cancers to survive the onslaught of various cancer therapies (Pillai et al., 2010), changes ... -
Single point mutations reveal amino acid residues important for Chromobacterium violaceum transaminase activity in the production of unnatural amino acids
(2018)Unnatural amino acids (UAAs) are chiral amines with high application potential in drug discovery and synthesis of other valuable chemicals. Biocatalysis offers the possibility to synthesise novel optically pure UAAs with ... -
Tubulin-targeting antiparasitic herbicides : new insights into putative ligand-binding pockets and computational design of molecular equivalents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Neglected diseases are a group of tropical infections which are especially endemic in lowincome populations in developing regions of Africa, Asia, and the Americas. Collectively these diseases affect more more than a biUion ... -
The relative role of IRAK-2 in TLR signalling
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NFkB and MAPKs such as p38. ... -
Immune modulation by the helminth parasite Fasciola hepatica
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)The incidence of allergic and autoimmune disease In the developed world has Increased dramatically In the past century. This has coincided with a reduction In the Incidence of infectious disease. The hygiene hypothesis ... -
Studies on the delirium-dementia continuum : CNS effects of systemic inflammation on hypocholinergia and chronic neurodegeneration
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Peripheral inflammation can signal to the normal, healthy CNS via multiple routes. During ageing and dementia, however, the brain is particularly susceptible to the deleterious effects of such insults. Delirium is an acute ... -
Ruthenium(11) metal complexes for photodynamic therapy (PDT) or as imaging agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Photodynamic therapy (PDT) represents a new localised method of treatment in cancer. The therapeutic effect is mediated by the generation of reactive oxygen species (ROS) and/or the formation of singlet oxygen (1 O2), a ... -
The pathogenesis of experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Multiple Sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) mediated by autoantigen-specific T cells. Experimental autoimmune encephalomyelitis (EAE) is an animal model for MS driven by ... -
Structural and biophysical investigations of Rab GTPase interacting proteins
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Summary: Rab GTPases are important regulators of cell trafficking steps such as vesicle fusion, budding and motility. They are often described as 'on/off' switches, interacting with specific effectors when bound to GTP. ... -
A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)All species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application ... -
An investigation into the role of TMED1 in IL-33/ST2L singalling pathway
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)This thesis set out to characterise the GOLD domain containing protein, TMED1 which had been shown to associate with ST2L, the receptor for the cytokine IL-33 and to investigate its relationship with ST2L. -
Immunoregulatory mechanisms in the lungs of mice and humans
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The lungs are constantly exposed to inhaled antigen during respiration. The resident immune cells must be hyporesponsive to innocuous inhaled antigen, yet capable of responding appropriately to respiratory pathogens, with ...
