Browsing Genetics (Scholarly Publications) by Subject "Genetics"
Now showing items 21-40 of 83
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Dual Origins of Dairy Cattle Farming Evidence from a Comprehensive Survey of European Y-Chromosomal Variation
(PLoS, 2011)Background: Diversity patterns of livestock species are informative to the history of agriculture and indicate uniqueness of breeds as relevant for conservation. So far, most studies on cattle have focused on mitochondrial ... -
Duplicability of self-interacting human genes.
(2010)Background: There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model ... -
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development.
(2014)Background Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master ... -
The effect of chaperonin buffering on protein evolution.
(2010)Molecular chaperones are highly conserved and ubiquitous proteins that help other proteins in the cell to fold. Pioneering work by Rutherford and Lindquist suggested that the chaperone Hsp90 could buffer (that is, suppress) ... -
Elusive origins of the extra genes in Aspergillus oryzae
(PLoS, 2008)The genome sequence of Aspergillus oryzae revealed unexpectedly that this species has approximately 20% more genes than its congeneric species A. nidulans and A. fumigatus. Where did these extra genes come from? Here, we ... -
Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi
(BioMed Central, 2008)Background Filamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis. Genes from the same pathway are often clustered and co-expressed in particular ... -
Evidence from comparative genomics for a complete sexual cycle in the "asexual" pathogenic yeast Candida glabrata
(BioMed Central, 2003)BACKGROUND: Candida glabrata is a pathogenic yeast of increasing medical concern. It has been regarded as asexual since it was first described in 1917, yet phylogenetic analyses have revealed that it is more closely related ... -
Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus
(2009)BACKGROUND: The comparative analysis of genome sequences emerging for several avian species with the fully sequenced chicken genome enables the genome-wide investigation of selective processes in functionally important ... -
Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents
(National Academy of Sciences, 2011)We investigate yeast sex chromosome evolution by comparing genome sequences from 16 species in the family Saccharomycetaceae, including data from genera Tetrapisispora, Kazachstania, Naumovozyma, and Torulaspora. We show ... -
Evolutionary Origins of the Fumonisin Secondary Metabolite Gene Cluster in Fusarium verticillioides and Aspergillus niger
(SAGE-Hindawi, 2011)The secondary metabolite gene clusters of euascomycete fungi are among the largest known clusters of functionally related genes in eukaryotes. Most of these clusters are species specific or genus specific, and little is ... -
Evolutionary steps of sex chromosomes are reflected in retrogenes
(2008)It has been shown that selective pressure to compensate for the silencing of the sex chromosomes during male meiosis resulted in many X-linked genes being duplicated as functional retrogenes on autosomes. Sex chromosome ... -
Expression of Plxdc2/TEM7R in the developing nervous system of the mouse.
(2007)Plexin-domain containing 2 (Plxdc2) is a relatively uncharacterised transmembrane protein with an area of nidogen homology and a plexin repeat (PSI domain) in its extracellular region. Here, we describe Plxdc2 expression ... -
Extensive gene gain associated with adaptive evolution of poxviruses
(2003)Previous studies of genome evolution usually have involved one or two genomes and have thus been limited in their ability to detect the direction and rate of evolutionary change. Here, we use complete genome data from 20 ... -
The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns.
(2007)BACKGROUND: Leucine-rich repeats (LRRs) are highly versatile and evolvable protein-ligand interaction motifs found in a large number of proteins with diverse functions, including innate immunity and nervous system development. ... -
Following the genes: a framework for animal modeling of psychiatric disorders.
(2011)The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models ... -
Fourfold faster rate of genome rearrangement in nematodes than in Drosophila
(2002)We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio ... -
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.
(2011)African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more ... -
The genetics of brain wiring: from molecule to mind.
(2007)What makes some people neurotic or schizophrenic or right-handed or fearless? Are these behavioural differences caused by literal differences in how individuals' brains are wired? If so, what causes those differences? This ... -
The genetics of neurodevelopmental disease
(Elsevier, 2011)The term neurodevelopmental disorder encompasses a wide range of diseases, including recognizably distinct syndromes known to be caused by very rare mutations in specific genes or chromosomal loci, and also much more common ...