Browsing Genetics (Scholarly Publications) by Subject "Genomes, Genomics"
Now showing items 1-9 of 9
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A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
(2015)Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ... -
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development.
(2014)Background Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master ... -
Exceptional ancient DNA preservation and fibre remains of a Sasanian saltmine sheep mummy in Chehrābād
(2021)Mummified remains have long attracted interest as a potential source of ancient DNA. However, mummification is a rare process that requires an anhydrous environment to rapidly dehydrate and preserve tissue before complete ... -
Gene expression changes during retinal development and rod specification
(2015)Purpose: Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely, eventually resulting in blindness. Gene therapies ... -
The N-end rule pathway regulates pathogen responses in plants.
(2016)To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination ... -
New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
(2015)The origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from ... -
Protein coadaptation and the design of novel approaches to identify protein-protein interactions
(2011)Proteins rarely function in isolation but they form part of complex networks of interactions with other proteins within or among cells. The importance of a particular protein for cell viability is directly dependent upon ...