Browsing Genetics (Scholarly Publications) by Subject "NLRP3 inflammasome"
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Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
(2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ...