Genetics (Scholarly Publications): Recent submissions
Now showing items 121-140 of 360
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Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs
(2016)Recent evidence has strongly implicated IL-36 cytokines as key initiators of inflammation in the skin barrier. IL-36 cytokines belong to the extended IL-1 family and, similar to most members of this family, are expressed ... -
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines
(2016)IL-36 cytokines require proteolytic processing for activation, but how this is achieved is unknown. Here, Henry et al. show that proteases liberated from activated neutrophils—cathepsin G, elastase, and proteinase-3 ... -
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
(2015)PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional repression and developmental gene regulation. Individual PCGF proteins define discrete Polycomb Repressor Complex 1 (PRC1) ... -
Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
(2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ... -
MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking
(2015)Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first ... -
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
(2015)Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ... -
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.
(2015)We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus ... -
Differential apicobasal VEGF signaling at vascular blood-neural barriers
(2014)The vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal ... -
A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
(2014)Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira . More than 500,000 cases of severe leptospirosis are reported annually, with . 10% ... -
Network plasticity in adaptive filtering and behavioral habituation
(2014)The ability of organisms to seamlessly ignore familiar, inconsequential stimuli improves their selective attention and response to salient features of the environment. Here, I propose that this fundamental but unexplained ... -
Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae.
(2014)Biological systems remain robust against certain genetic and environmental challenges. Robustness allows the exploration of ecological adaptations. It is unclear what factors contribute to increasing robustness. Gene ... -
Specification of floral organs in Arabidopsis
(2014)Floral organs are specified by the activities of a small group of transcriptional regulators, the floral organ identity factors. Extensive genetic and molecular analyses have shown that these proteins act as master regulators ... -
RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis
(2014)Tumour necrosis factor and lipopolysaccharide can promote a regulated form of necrosis, called necroptosis, upon inhibition of caspase activity in cells expressing receptor-interacting serine/threonine kinase (RIPK)3. ... -
Bcl-2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1-dependent mitophagy
(2014)Mitophagy facilitates the selective elimination of impaired or depolarized mitochondria through targeting the latter to autophagosomes. Parkin becomes localized to depolarized mitochondria in a PINK1-dependent manner and ... -
Functional conservation of an ancestral Pellino protein in helminth species
(2015)The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms such as ... -
Patterns of gene expression during Arabidopsis flower development from the time of initiation to maturation
(2015)Background The formation of flowers is one of the main model systems to elucidate the molecular mechanisms that control developmental processes in plants. Although several studies have explored gene expression during ...
