Genetics (Scholarly Publications): Recent submissions
Now showing items 341-360 of 360
-
RP1 Consortium. Identification of the RP1 and RP10 (IMPDH1) genes causing autosomal dominant RP
(Springer, 2003)Given that mutant COL1A1 is known to cause Osteogenesis Imperfecta (OI), tools to modulate COL1A1 expression are likely to be of significant therapeutic value. In this context, we have evaluated RNA interference (RNAi) as ... -
RNAi of COL1A1 in mesenchymal progenitor cells
(Nature Publishing Group, 2004)Given that mutant COL1A1 is known to cause Osteogenesis Imperfecta (OI), tools to modulate COL1A1 expression are likely to be of significant therapeutic value. In this context, we have evaluated RNA interference (RNAi) as ... -
Cone opsin mislocalization in Rpe65-/- mice: A defect that can be corrected by 11-cis retinal
(The Association for Research in Vision and Ophthalmology, Inc., 2005)PURPOSE: In retinal degenerative diseases, rod photoreceptors typically deteriorate more rapidly than cone photoreceptors. In the Rpe65(-/-) mouse, a model for Leber's congenital amaurosis, cones degenerate much more rapidly ... -
Synaptic plasticity in GNGA3-/- mice: Cone bipolar cells react up0onthe missing cone input and form ectopic synapses with rods
(The Society for Neuroscience, 2006)In the mammalian retina, rods and cones connect to distinct sets of bipolar cells. Rods are presynaptic to a single type of rod bipolar cell, whereas cones connect to different types of cone bipolar cells. Synaptic rewiring ... -
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa.
(2007)Background The role played by microRNAs (miRs) as common regulators in physiologic processes such as development and various disease states was recently highlighted. Retinitis pigmentosa (RP) linked to RHO (which encodes ... -
Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram.
(Association for Research in Vision and Ophthalmology, 2008)PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake ... -
Rod and cone contributions to horizontal cell light responses in the mouse retina.
(The Society for Neuroscience, 2008)Mammalian B-type horizontal cells make contact with both photoreceptor types: the dendrites contact cone photoreceptors, whereas the axon terminal processes contact rods. Despite their distinct synaptic contacts, horizontal ... -
An experimental platform for systemic drug delivery to the retina
(2009)Degenerative retinopathies, including age-related macular degeneration, diabetic retinopathy, and hereditary retinal disorders?major causes of world blindness?are potentially treatable by using low-molecular weight ... -
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
(2009)Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to ... -
Clusters of co-expressed genes in mammalian genomes are conserved by natural selection
(Oxford University Press, 2005)Genes that belong to the same functional pathways are often packaged into operons in prokaryotes. However, aside from examples in nematode genomes, this form of transcriptional regulation appears to be absent in eukaryotes. ... -
Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons
(Oxford University Press, 2005)Alternative splicing is known to be an important source of protein sequence variation, but its evolutionary impact has not been explored in detail. Studying alternative splicing requires extensive sampling of the transcriptome, ... -
Darwin's Irish correspondence
(Royal Irish Academy, 2008)Searches of Darwin?s correspondence show that some 160 letters crossed between him and naturalists and others with an Irish address. While few in number, compared to Darwin?s 14,000 other known letters, some of this ... -
Correspondence of Charles Darwin on James Torbitt's project to breed blight-resistant potatoes
(Edinburgh University Press, 2008)The most prolific of Darwin?s correspondents from Ireland was James Torbitt, an enterprising grocer and wine merchant of 58 North Street, Belfast. Between February 1876 and March 1882, 141 letters were exchanged on the ... -
Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts.
(2006)A whole-genome duplication occurred in a shared ancestor of the yeast species Saccharomyces cerevisiae, Saccharomyces castellii and Candida glabrata. Here we trace the subsequent losses of duplicated genes, and show that ... -
Rate asymmetry after genome duplication causes substantial long-branch attraction artifacts in the phylogeny of Saccharomyces species
(Oxford University Press, 2006)Whole-genome duplication (WGD) produces sets of gene pairs that are all of the same age. We therefore expect that phylogenetic trees that relate these pairs to their orthologs in other species should show a single consistent ... -
Functional Partitioning of Yeast Co-Expression Networks after Genome Duplication
(Public Library of Science, 2006)Several species of yeast, including the baker?s yeast Saccharomyces cerevisiae, underwent a genome duplication roughly 100 million years ago. We analyze genetic networks whose members were involved in this duplication. ... -
Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser
(Oxford University Press, 2006)The Yeast Gene Order Browser (YGOB) is an online tool designed to facilitate the comparative genomic visualization and appraisal of synteny within and between the genomes of seven hemiascomycete yeast species. Three of ... -
The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species
(2005)We developed the Yeast Gene Order Browser (YGOB; http://wolfe.gen.tcd.ie/ygob) to facilitate visual comparisons and computational analysis of synteny relationships in yeasts. The data presented in YGOB, currently covering ... -
Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach
(2008)Background: Poxviruses are important pathogens of humans, livestock and wild animals. These large dsDNA viruses have a set of core orthologs whose gene order is extremely well conserved throughout poxvirus genera. They ...
