Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Subject "Ph.D. Trinity College Dublin"
Now showing items 21-40 of 88
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Design, synthesis and evaluation of indazoles as antiproliferative agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Cancer is a leading cause of death in most countries, second only to the diseases of the circulatory system. In relation to Ireland, cancer accounted for 29.6 % of all the deaths reported in 2012. After non-melanoma skin ... -
Design, synthesis and evaluation of novel tumour vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)This thesis is introduced with a review of the 'Hallmarks of Cancer', outlining each one as a potential target for drug therapy. Vascular targeting as a means of cancer growth retardation is specifically discussed. The ... -
Development of microemulsions and self-emulsifying systems for oral drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as ... -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ... -
Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents ... -
Engineering a novel insulin delivery system
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis investigated the preparation of a novel system that would be suitable for the oral delivery of insulin. The genetic modification of insulin gene to establish a simple system of insulin production ... -
Formulation and characterisation of polyelectrolyte complex nanoparticles for the delivery of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis explored the formulation of various polyelectrolyte complex nanoparticles as potential carriers for the delivery of macromolecules. The complexes were formed between a polyanion (hyaluroninc acid, ... -
Formulation of protein and DNA microparticulate vaccine systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This study involved investigation of protein and DNA-loaded microspheres manufactured with a range of polymers and under different manufacturing conditions. The polymers used during encapsulation were poly (lactide-co-glycolide) ... -
Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical ... -
Functional expression of the epithelial sodium channel δ-subunit in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Mammalian amiloride-sensitive epithelial Na+ channel (ENaC) can be composed by different combinations of four homologous subunits, α, β, γ and δ. The canonical αβγ- ENaC, abundantly expressed in Na+ absorbing epithelia, ... -
Hormonal and emotional regulation of memory processes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis comprises two areas of study. The first study examined the effect of the menstrual cycle on Event-Related Potentials (ERPs) and verbal memory, as measured by paragraph recall and paired associates, and mood, ... -
Influence of anti-inflammatory interventions in the Kainic acid model of hippocampal excitotoxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodegenerative disorders. Such toxicity can be induced experimentally by systemic administration of the glutamate kainate receptor agonist, ... -
Intestinal degradation and absorption kinetics of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The aim of this work was to investigate the intestinal degradation and absorption of a hydrophilic peptide, salmon calcitonin (sCT), and to evaluate the use of bile salt simple and mixed micellar systems as potential ... -
Intestinal lymphatic transport of DDT and Saquinavir : the role of lipid based formulations and modulators of P-Glycoprotein and Cytochrome P450
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The experiments in this thesis represent biopharmaceutical investigations, performed in an attempt to evaluate potential dosage form strategies designed to promote the intestinal lymphatic transport of lipophilic compounds. ... -
Intracellular and extracellular biomarkers predictive of response to anti-cancer treatments for breast and prostate cancer
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Cancer remains one of the leading causes of death worldwide. Breast and prostate cancer are the most frequently diagnosed cancers among women and men, respectively. Despite some breakthroughs in their treatment, innate or ... -
Investigation into bile acid effects on the golgi apparatus, cell viability and glucocorticoid receptor distribution in esophageal cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Bile acids are a family of steroidal molecules derived from cholesterol and biosynthesised in the pericentral hepatocytes in the liver. In recent years there has been a renaissance in bile acid based research as it has ... -
Investigation of cerebral perfusion changes following MDMA Ecstasy administration in an animal model using bolus-tracking arterial spin labelling MRI
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The recreational drug of abuse 3,4 methylenedioxymethamphetamine (MDMA; Ecstasy) carries a risk of cerebrovascular accidents (CVA) that may relate to the role of serotonin (5- HT) and/or dopamine in the regulation of ... -
Investigation of factors affecting dissolution under biorelevant low velocity hydrodynamic conditions, using in vitro and in-silico methods
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The goals of the current study were to investigate the effect of hydrodynamics on the dissolution of non-disintegrating compacts in a low velocity environment. This work also studies the impact of hydrodynamics on the ... -
Investigation of ibuprofen release from ethylcellulose matrix compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)A comprehensive study of ethylcellulose powder and ethylcellulose compacts (of different ethylcellulose viscosity grades) was undertaken. Studies showed that the lower viscosity grade ethylcellulose (4 cP) was more ...