Pharmacy and Pharmaceutical Sciences (Theses and Dissertations): Recent submissions
Now showing items 1-20 of 170
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Identifying and addressing uncertainties regarding the tapering of psychiatric medications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, 2025)Background: There is a cohort of individuals looking to discontinue use of psychiatric medication. Tapering is the recommended approach for reducing and/or stopping the use of psychiatric medication. This involves ... -
Investigation of an Essential Oil Blend as a Complementary Therapy to Reduce Stress and Aid Relaxation.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Aromatherapy is the therapeutic use of essential oils extracted from plants to support health and wellbeing. In recent years, the practice of aromatherapy, has been increasingly integrated into clinical settings to support ... -
Phytochemical Analysis and Anti-Inflammatory Activity of Capparis cartilaginea Decne. from Saudi Arabia: An Ethnopharmacological Study
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Background: Capparis cartilaginea (C. cartilaginea) is a species belonging to the Capparaceae family, which is known for its various traditional medicinal uses. In Saudi Arabia, the leaves and roots of C. cartilaginea are ... -
Characterising the Effect of Hypoxic Conditions on Extracellular Vesicle Release and Function in Triple-Negative Breast Cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Hypoxia is a hallmark of many solid tumours and is strongly associated with cancer progression and metastasis. Triple-negative breast cancer (TNBC), an aggressive subtype lacking targeted therapies, exhibits more pronounced ... -
Design and Synthesis of Potent and Selective Anticancer Compounds Targeting Tubulin Polymerisation and Aminopeptidase N
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)This thesis describes the synthesis and evaluation of novel drug conjugates targeting aminopeptidase N (APN) (E.C. 3.4.11.2) and tubulin dynamics. Chapter 1 opens with a thorough review of the existing literature on ... -
MEDICINAL CHEMISTRY STUDIES ON DIANHYDROHEXITOLS AS SCAFFOLDS FOR NOVEL ANTI-INFLAMMATORY DRUG DESIGN
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)This thesis focuses on the design, synthesis, and evaluation of novel anti‐inflammatory compounds using dianhydrohexitol scaffolds. The primary aim was to develop more potent alternatives to the lead compound, ST0702, ... -
Long-Term Use of Medications with Anticholinergic Activity in Older Adults with Intellectual Disability: Prescribing Challenges and Impact on Health Outcomes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Background: Older adults with intellectual disability are exposed to polypharmacy and a high anticholinergic burden due to the high prevalence of mental and neurological disorders. A cumulative anticholinergic burden has ... -
Synthesis and physicochemical analysis of pyrazinib and quininib prodrugs and discovery of novel cysteinyl leukotriene receptor 1 antagonists
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Gastrointestinal cancers, particularly oesophageal adenocarcinoma (OAC), are aggressive diseases with a poor 5-year survival rate of less than 20%. Current treatment for OAC is neoadjuvant therapy, including chemotherapy ... -
Development of novel image-based computational and artificial intelligence (AI) technologies for real time monitoring and event detection during in vitro dissolution testing
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)To ensure safe and effective medications, in recent years the ever evolving pharmaceutical industry started to transform and to adopt novel technologies for continuous manufacturing, real time monitoring and quality control. ... -
Solid-State Transformations of Fluoroquinolones Induced by Mechano- and Tribo-Chemical Processes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Mechano- and tribo-chemistry is growing at a fast rate. However, more scientific contributions need to be made in order to better understand this type of chemistry and processing so that it can be implemented into the ... -
The impact of pharmacological modulation of the NMDA-receptor/NO signalling pathway on neuronal complexity in vitro
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Neuronal atrophy and alterations in dendritic and synaptic structure are associated with multiple central nervous system (CNS) disorders ranging from acute neurological injuries to chronic neurodegenerative diseases and ... -
Synthesis and biological evaluation of novel pyrazolyl 1, 4-dihydropyridines, 1,2,3,4-tetrahydropyrimidines and related compounds as antiproliferative agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)This thesis reports the design, synthesis, characterisation and biological evaluation of novel dihydropyridines, tetrahydropyrimidines and structurally related compounds. Therapeutically used as calcium channel blockers ... -
Engineering of itraconazole nano- and microparticles with improved pharmaceutical performance
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Itraconazole (ITR) is an antifungal drug with limited bioavailability due to its poor aqueous solubility. In this work, ITR was used to investigate unexplored and/or previously reported as infeasible formulation approaches ... -
The impact of kynurenine pathway activation in glia on neuronal integrity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2017)The kynurenine pathway, which is activated in times of stress and infection has been implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Alterations in neuronal integrity, including neuronal ... -
A Comparison of Spray drying and Liquid Antisolvent Co-precipitation for the Generation of Two- and Three- component Amorphous Solid Dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)The thesis focuses on the use of different manufacturing techniques for the generation of amorphous solid dispersions (ASDs) for the enhancement of the solubility of model compounds. ASDs with hydrochlorothiazide (HCTZ) ... -
Exploring the potential impact of collaborative medicines optimisation involving pharmacogenomic testing and general practice pharmacists in primary care in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, University of Dublin, Trinity College, 2024)Introduction People are living longer, but not necessarily in better health. The ageing population coupled with the rise in chronic conditions has led to many older people being prescribed polypharmacy, which may not always ... -
Assessment of milk extracellular vesicle (EV) in vitro bioactivity
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, School of pharmacy and pharmaceutical science, 2024)Extracellular Vesicles (EVs) are small particles involved in cell-to-cell communication. They have been identified in numerous biological fluids, including milk. Milk EVs serve to communicate between mother and infant, ... -
Pharmaceutical Solid Forms and Formulations for Enhanced Solubility and Dissolution: Cocrystals, Salts, and Crystalline Solid Dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This thesis focuses on the development, manufacture, and characterisation of cocrystals and salts and their formulations, to enhance the solubility and dissolution of poorly soluble drugs. Three poorly soluble active ... -
Using in vitro and in silico approaches to investigate ibuprofen particulate and formulation dissolution behaviour under different hydrodynamic conditions.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This work investigated the effect of fluid velocity and medium viscosity on the dissolution of ibuprofen powder and ibuprofen immediate release tablets in vitro, in the paddle apparatus and the flow-through apparatus, and ... -
The treatment of obesity using magneto -mechanical effect
Obesity is a very prevalent condition that can be very often associated with the development of comorbidities, such as insulin resistance, hypertension, and hyperlipidaemia that can lead to cardiovascular and cerebrovascular ...
