Pharmacy and Pharmaceutical Sciences (Theses and Dissertations): Recent submissions
Now showing items 141-160 of 170
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Investigation of ibuprofen release from ethylcellulose matrix compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)A comprehensive study of ethylcellulose powder and ethylcellulose compacts (of different ethylcellulose viscosity grades) was undertaken. Studies showed that the lower viscosity grade ethylcellulose (4 cP) was more ... -
Neuronal Nitric oxide synthase : a novel target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main ... -
Production and characterisation of spray dried particulate systems for pulmonary drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The work presented in this thesis concerns the application of a particle engineering technology, one-step spray drying method, to produce porous particles of antitubercular drugs, suitable for inhalation and to study the ... -
Blood biocompatiblity of polyvinyl, chloride surface-modified with multi-walled carbon nanotubes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Blood-surface interaction in extracorporeal circuits (for example, cardiopulmonary bypass) requires the infusion of a systemic anticoagulant to prevent devastating thrombus formation. Platelet activation upon contact with ... -
Studies on the design, synthesis and stability of novel anti-allergy agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The purpose of this project was to design and synthesise novel classes of anti-allergy compounds using 1-tetralone as the principal building block. This thesis is introduced with an overview of the prominent role played ... -
Characterisation of drug transporters in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cell culture models are an efficient and relatively cheap tool to study isolated mechanisms of an organ. The right cell model, carefully selected to allow highest benefits, can give valuable information in the area of ... -
Mechanistic aspects of the degradation and drug release properties of poly-alpha-hydroxyl aliphatic ester nano- and microparticle
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Particulate systems based on the polymers of lactic and glycolic acids have been extensively investigated as drug delivery technologies, particularly as vehicles to achieve controlled release. The release kinetics from ... -
Engineering a novel insulin delivery system
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis investigated the preparation of a novel system that would be suitable for the oral delivery of insulin. The genetic modification of insulin gene to establish a simple system of insulin production ... -
Investigation of the PSD-95 / nNOS protein interaction as a target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Previous studies have demonstrated that nitric oxide (NO) synthase inhibitors are as efficacious as tricyclic antidepressants in preclinical antidepressant screening procedures and in attenuating behavioural deficits ... -
Intracellular and extracellular biomarkers predictive of response to anti-cancer treatments for breast and prostate cancer
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Cancer remains one of the leading causes of death worldwide. Breast and prostate cancer are the most frequently diagnosed cancers among women and men, respectively. Despite some breakthroughs in their treatment, innate or ... -
Design and synthesis of tubulin-binding agents, and their incorporation into novel dual-acting hybrid molecules targeting the tumour vasculature
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis involves the design and synthesis of tubulin binding agents, which aside from their anti-proliferative impact, seek to induce anti-vascular and anti-angiogenic responses on the unique vasculature derived by a ... -
Synthetic amorphous silica nanoparticles induce human endothelial cell inflammation and platelet aggregation : role of NF-kB and reactive nitrogen species
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: The human population has been exposed to nanoparticles (particles with nano-dimensions) throughout all its evolutionary process; however, this exposure has been increased since the industrial ... -
An investigation of the potential anti-inflammatory properties of novel compounds with respect to LFA-1 mediated T cell motility and cytotoxicity profiling
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The aim of this thesis was to investigate the effects in vitro of novel compounds on LFA-1 mediated T cell motility, and, to develop a profile of the compounds with respect to cytotoxicity and apoptosis. The compounds ... -
The synthesis and biological evaluation of a novel class of butyrylcholinesterase inhibitors using isosorbide as a building block
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this project was to synthesise and optimise a novel class of cholinesterase inhibitors using the simple sugar, isosorbide, as a building block and to assess the inhibitory activity of these compounds in vitro. ... -
Use of computational fluid dynamics to investigate the relationship between hydrodynamics and rates of dissolution
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The hydrodynamics within the paddle (900 ml), basket (900 ml) and Levy beaker (350 ml and 550 ml) (Levy et al., 1965) dissolution apparatuses were simulated using the computational fluid dynamics (CFD) package, Fluent™. ... -
The influence of drug physicochemical properties on release from thermoresponsive smart hydrogels
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Thermoresponsive hydrogels are a class of "smart" or "environmentally sensitive" systems with potential for controlling the release of a drug in response to a specific stimulus. Previous research in the area of thermoresponsive ... -
Preparation and characterisation of spray dried composites of pharmaceutical materials
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The solid state properties of a range of spray dried excipients and drugs and co-spray dried excipient/excipient, drug/excipient and drug/drug, systems were investigated. The excipients investigated were lactose, polyethylene ... -
An investigation on the therapeutic properties of novel compounds in models of asthma, inflammation and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)There are many drugs on the market for the treatment of asthma, inflammation and delayed type hypersensitivity (DTH), however few are disease modifying. The potential therapeutic effect of three novel compounds, 3C8, 6C6 ... -
Kinetic and structural studies of novel isosorbide-based ligand binding to esterase enzymes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The main goal of the project described herein was to examine and rationalise the binding of a novel class of compound based on isosorbide to cholinesterase enzymes. The compounds of interest had been prepared within the ... -
An exploration of the role of community pharmacists in the supply of benzodiazepines and Z-drugs in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)This thesis set out to explore community pharmacists' role in the supply of benzodiazepines and Z-drugs in Ireland. The introductory chapter outlines how the research undertaken sought to address a notable gap in the ...
