Pharmacy and Pharmaceutical Sciences (Theses and Dissertations): Recent submissions
Now showing items 161-170 of 170
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Warfarin therapy in the Republic of Ireland : the potential role of neural networks in optimising therapy
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Anticoagulant therapy is used to reduce the embolic risk associated with many diseases e.g. atrial fibrillation, deep vein thrombosis and aortic valve replacement. The decision to anticoagulate a patient is made individually, ... -
The role of the community pharmacist in optimising patients' inhaler use in asthma management
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The Asthma Insights and Reality in Ireland survey revealed that only 8% of those surveyed had controlled asthma, as defined by evidence-based guidelines. A detailed analysis of patients’ abilities to use their inhalation ... -
Cytokine-induced epithelial-mesenchymal transition : mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Fibrosis is characterised by the accumulation of myofibroblasts, the key effector cell implicated in the fibrogenic reaction. The exact origin of these myofibroblasts remains poorly understood. However, growing evidence ... -
Formulation of protein and DNA microparticulate vaccine systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This study involved investigation of protein and DNA-loaded microspheres manufactured with a range of polymers and under different manufacturing conditions. The polymers used during encapsulation were poly (lactide-co-glycolide) ... -
The design, synthesis and preliminary evaluation of prodrugs and hybrid drugs with tubulin polymerisation inhibitory activity and anti-proliferative activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The objective of this project was to design, synthesise and carry out preliminary evaluations on potential prodrugs and hybrid drugs with anti-proliferative effects. Chapter 1 gives an overview of current trends in cancer ... -
The effect of processing on the solid state characteristis of selected sulphonamides and their sodium salts, alone and as drug-salt composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The purpose of the research presented in this thesis was to produce metastable active pharmaceutical ingredients (API) by spray drying and to analyse, physico-chemically characterise these forms and develop strategies to ... -
Optimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The use of the pulmonary route is a viable alternative administration route to injection, in particular for drugs with poor systemic bioavailability upon oral delivery such as therapeutic peptides and proteins. However, ... -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Development of microemulsions and self-emulsifying systems for oral drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as ... -
An investigation of the impact of experimental colitis and inflammatory bowel disease on behaviour and on systemic and central inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Inflammatory bowel diseases (IBD) are chronic conditions characterised by uncontrolled inflanmiation of the intestinal mucosa. Clinical symptoms include weight loss, diarrhoea, rectal bleeding and abdominal pain. In addition ...
