Pharmacy and Pharmaceutical Sciences (Theses and Dissertations): Recent submissions
Now showing items 41-60 of 170
-
Development and evaluation of novel, personalisable electronic counselling aids for patients starting Direct Oral Anticoagulants (DOACs)
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Comprehensive education for patients taking DOACs is essential to ensure treatment is safe and efficacious. The prescribing of DOACs has increased since becoming available on the European market in 2008, as evidence shows ... -
Chemical biology studies on human and mouse secondary bile acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Bile acids are important regulators of multiple homeostatic mechanisms integrating cell proliferation, metabolism and inflammation. The overall objective of this thesis was to use chemical biology tools to understand ... -
Investigations of extracellular vesicles in triple-negative breast cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Breast cancer is the most commonly diagnosed cancer worldwide accounting for 11.7% of the newly diagnosed 19.3 million cases in 2020. In Ireland breast cancer accounted for 10.8% of cancer cases and 23.8% of female cancers. ... -
A Scientific Evaluation of Traditional Chinese Medicine (TCM): Houttuynia cordata Thunb Saururaceae - A Case Study
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Traditional Chinese Medicine (TCM) is one of the oldest medical systems in the world, still used for prevention or treatment of diseases in the modern China. It is a unique and holistic system, guided by ancient Chinese ... -
C6 glioma neuronal interactions and their moderation by the tryptophan-kynurenine metabolism pathway
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Brain glia possess the rate limiting enzyme indoleamine 2, 3-dioxygenase (IDO) which catalyses the conversion of tryptophan to kynurenine. Microglia also express kynurenine monooxygenase (KMO) and kynureninase (KYNU) which ... -
Design and development of a hydrogel formulation with nanoparticles for the treatment of glioblastoma multiforme
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Glioblastoma multiforme (GBM) is the most aggressive form of brain tumours. GBM treatment is challenging because tumours are highly invasive and it is difficult to achieve effective therapeutic doses of drugs into the ... -
Development of new pharmacological agents for the treatment of T cell diseases of the skin
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020) -
Discovery of therapies for lymphomas and leukaemia: Synthesis and antiproliferative action of novel ethanoanthracenes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Cancer is a broad class of diseases responsible for up to 9.6 million deaths worldwide in 2018, accountable for approximately every one in six deaths globally. Cancer is second only in all-cause mortality to circulatory ... -
A study of glial associated changes in the complexity of primary cortical neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Neuroinflammation and disruptions in the integrity of neuronal circuitry are hallmarks of a range of CNS disorders. There is extensive evidence linking pro-inflammatory signalling and glial dysfunction with neuronal atrophy ... -
Role of kynurenine on platelet's function and beyond
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase enzyme in other tissues. Although it has been shown that ... -
New solid forms of itraconazole and their pharmaceutical applications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Itraconazole (ITR) is an active pharmaceutical ingredient (API) with a broad-spectrum antifungal activity. This API has a very low solubility, which can hinder its bioavailability after oral administration. In this work, ... -
Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble active pharmaceutical ingredients
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)This thesis focuses on factors affecting the stability and performance of amorphous solid dispersions (ASDs) of poorly soluble active pharmaceutical ingredients (APIs). The poor aqueous solubility of pipeline drugs has ... -
The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus and cardiovascular diseases (CVDs). FDC products with ... -
The production of crystalline powders by spray drying to improve the mechanical and flow properties of an active pharmaceutical ingredient
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The overall aim of this research was to crystallise a drug onto the surface of an excipient (EXP) using a spray dryer in order to improve the processability of the attached active pharmaceutical ingredient (API). The project ... -
Effect of 2-amino imidazoline derivatives on tumour cell-induced platelet aggregation
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Platelets play a central role in thrombosis and haemostasis. However, platelets can also aggregate in the presence of tumour cells in a phenomenon known as tumour-cell-induced-platelet-aggregation (TCIPA). During this ... -
Factors associated with the use of gastrointestinal medicines amoung older people with intellectual disabilities in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Background: People with intellectual disabilities (ID) experience multi-morbidity, multiple medication use and have complex health needs. Gastrointestinal (GI) disorders such as constipation and gastroesophageal reflux ... -
Addressing the complexity of medication use in older people with intellectual disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Background: People with intellectual disabilities (ID) experience high levels of polypharmacy and medication burden. Many of the most commonly occurring medical conditions in older adults with ID are treated with medications ... -
Costs and outcomes of cancer care in older adults : population-based analysis
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Cancer is a major cause of mortality worldwide. The disease disproportionately affects the older population and 60% of new cancer cases and 70% of cancer-related deaths occur in individuals aged 65 or older. Large national ... -
Prevalence, patterns and factors associated with multiple medicines use in an ageing poulation with intelletual disability in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The provision of rational and appropriate pharmacotherapy to older people with intellectual disabilities (ID) poses significant challenges due to the complexities of conditions being treated, the increased risks of adverse ... -
Moral reasoning competencies development in community pharmacists in Ireland : a repeated measures crossover study
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Research suggests that higher levels of moral reasoning competencies increase the probability that community pharmacists will make decisions in the patient's 'best interests'. Professional ethics education incorporates the ...
