Pharmacy and Pharmaceutical Sciences (Theses and Dissertations): Recent submissions
Now showing items 61-80 of 170
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Mechanistic studies into the effect of deoxycholic acid on oesophageal cancer initiation and progression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Oesophageal cancer is the ranked as the fifth highest cancer in terms of cancer-related deaths worldwide and has an incidence rate that is increasing by 5% annually. Survival rates for oesophageal cancer are approximately ... -
Design and biological activity of a novel bioactive indane scaffold
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)This project is focussed on the design, synthesis and pharmacological evaluation of novel drug-hybrids which combine anti-inflammatory and anti-tumour activities to target the interface between inflammatory disease and ... -
Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma occurring with high incidence in developing areas such as equatorial Africa and Papua New Guinea. Within these tropical regions of high incidence (40-50 per 10 6), ... -
An exploration of the role of community pharmacists in health promotion in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)A combination of qualitative and quantitative methodologies was used to explore the research questions from a number of different angles. A literature review was carried out to identify work which had already been published ... -
Chemistry and Biology studies on anti-inflammiatory bile acid derivatives
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Abstract The objective of the dissertation is to clarify the potency, cytotoxicity and metabolism of novel steroidal anti-inflammatory compounds in the treatment inflammatory bowel disease (IBD). Biochemical methods with ... -
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the production of cocrystal-in-excipient systems by a variety of advanced pharmaceutical methods, such as spray drying, hot melt extrusion and spray coating. The production of cocrystal-in-excipient ... -
The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ... -
Targeting glial B2-adrenoceptors for immunododulation & neuoprotection in a rat model of Parkinson's disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Neuro-inflammation is a key contributor to the pathogenesis of Parkinson’s disease (PD). Brain-resident microglia are dynamic cellular effectors of inflammation-mediated neurodegeneration in the Parkinsonian brain. Here ... -
The production and characterisation of itraconazole multicomponent systems
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the poorly soluble triazole antifungal agent, itraconazole (ITZ). This compound was reported to form hydrochloride salts and cocrystals with a wide range of aliphatic dicarboxylic acids, which have ... -
Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Breast cancer is the most common female cancer diagnosed worldwide. In 2018 alone, there were over 2 million new breast cancer cases diagnosed. In Ireland, breast cancer is the most commonly diagnosed cancer in women. In ... -
Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis includes synthesis of various tubulin binding agents and their incorporation in to novel dual acting hybrids, which along with the tubulin inhibition also exhibit aminopeptidase N (APN) inhibition activities. This ... -
Electronic Counselling for Oral Anticoagulant Patients
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Education is an essential part of care for patients taking oral anticoagulants. However, it may be time-consuming for health care providers and overwhelming for patients, and hence sometimes suboptimal. Technology-based ... -
The optimisation, characterisation and platelet compatibility of polymeric nanocarriers loaded with NSAIDs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)There is a constant drive towards improving global health by continuously enhancing the quality of drugs available and the systems to deliver these drugs efficiently in order to treat disease. This thesis focused on the ... -
Investigation of the solid-state, powder flow and tabletability properties of comminuted active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)An understanding of the effect of processing on the solid-state properties of active pharmaceutical ingredients (APIs) is essential for product manufacturing success. During product development it is possible to induce ... -
Simulations of hydrodynamics in the paddle dissolution apparatus and dissolution from multi-layered compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Studies involving the calculation of dissolution rates from individual surfaces of large single component compacts, to assist in the prediction of dissolution rates from simple layered compact systems, revealed that ... -
An investigation to optimise teicoplanin therapy in patients with haematological malignancy and Gram-positive infection
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)This research was prompted by concerns of Tallaght Hospital, a major teaching hospital in Dublin, Ireland, that the dosage regimen for teicoplanin in patients with haematological malignancy was suboptimal. Three studies ... -
Characterisation of the functional role of OCTN1 in the pathogenesis of COPD
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The organic cation transporter (OCTN1) has been reported to play a role in the pathogenesis and development of inflammatory diseases. However, this association remains conflicting. Without fully elucidating the physiological ... -
Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The aetiology of inflammatory bowel disease (IBD) is incompletely understood but it is generally accepted to involve a dysregulated intestinal immune response to commensal microbiota and an increase in intestinal permeability. ... -
Effect of hydrodynamics on dissolution rate of poorly soluble drugs in the flow through apparatus
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009) -
The role of community pharmacists in disease prevention: A study of the delivery of clinical pharmacy services in community pharmacy in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The Role of Community Pharmacists in Disease Prevention: A Study of the Delivery of Clinical Pharmacy Services in Community Pharmacy in Ireland Susan O Dwyer Aims The overall aim of this research was to explore the role ...
