Pharmacy and Pharmaceutical Sciences (Theses and Dissertations): Recent submissions
Now showing items 81-100 of 170
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The specialist pharmacist and quality indicators of medication use in the care of people with intellectual disabilities and behaviour disorders
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Quality Medication Use and the Population with Intellectual Disabilities and Behaviour Disorders. A Modified Delphi Technique to develop Quality Indicators and a Grounded Theory approach to information provided by people ... -
The Gut-Brain Axis in Inflammatory Bowel Disease: Assessment of the Central Inflammatory Response to Dextran Sulfate Sodium-Induced Colitis in Rats
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory condition of the gastrointestinal (GI) tract. Evidence indicates a comorbidity between IBD and psychological symptoms in patients. It is thought ... -
Phytochemical studies on Choisya x dewitteana 'Aztec Pearl'
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The thesis is introduced with a review of the genus Choisya. Here emphasis is placed on the botany, traditional uses, phytochemistry and ethnopharmacological studies. The main classes of compounds found in the genus are ... -
Targeting the NMDA receptor/NO signalling pathway following L-α aminoadipic acid-induced astrocytic impairment and associated changes in the structural plasticity of neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)This investigation firstly aims to characterise the impact of astrocytic dysfunction on neurons in vitro, specifically the effects of L-α amino adipic acid (L-AAA)-induced astrocytic dysfunction on neurite outgrowth and ... -
Understanding the role of low glass transition temperature excipients in the mitigation of amorphisation on mechanical processing
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Commonly employed pharmaceutical processes such as milling, blending and compaction may unintentionally lead to the generation of amorphous regions or metastable polymorphic forms in crystalline active pharmaceutical ... -
The production and characterization of fluoroquinolone amorphous solid dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Ciprofloxacin (CIP) is a Biopharmaceutics Classification System class 4 drug, which exhibits solid-state limited solubility. Among the different formulation options available to improve the solubility of such a compound, ... -
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration on different anticoagulant modalities
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Uncertainty remains concerning pharmacokinetics (PK) of antimicrobials in critically ill patients due to the scarcity of data and the variable physiology of the patient cohort. This project incorporates two distinct aims. ... -
Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed ... -
Stereoselective synthesis of novel tubulin inhibitors with diverse functionality for integration into molecular conjugates and designed multiple ligands
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The principal objective of the work described in this thesis was the synthesis of a series of novel tubulin inhibitors, with defined stereochemistry and diverse functionality, suitable for the formation of molecular ... -
Multimodal magnetic resonance imaging in animal models of depression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Depression Is a debilitating and potentially fatal disorder for which the pathophysiology underlying the illness is still unknown. Aberrant glutamatergic neurotransmission and altered astrocyte function have recently been ... -
The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The purpose of the work undertaken within this project was to design and synthesis novel anti-cancer targeting compounds building upon previous work undertaken under the supervision of Dr. John J. Walsh in the School of ... -
Investigatons of the potential of crystalline excipients to prevent the process-induced amorphisation of active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)The focus of this thesis was to evaluate the impact of mechanical activation (milling and dry mixing) and spray drying on the crystallinity of selected active pharmaceutical ingredients (APIs) and to explore the feasibility ... -
Design, synthesis and evaluation of indazoles as antiproliferative agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Cancer is a leading cause of death in most countries, second only to the diseases of the circulatory system. In relation to Ireland, cancer accounted for 29.6 % of all the deaths reported in 2012. After non-melanoma skin ... -
The synthesis of novel mast cell stabilisers from benzocycloalkanones
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The purpose of this project was to design and synthesise novel classes of mast cell stabilisers from benzocycloalkanones. This thesis is introduced with an overview of the increasing prevalence of allergic conditions ... -
Investigations into the anti allergy properties of novel benzocycloalkanone based compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)An allergic response occurs because of a hypersensitive response by mast cells to an otherwise innocuous environmental substance. Allergen challenge causes mast cell degranulation, resulting in the release of mast cell ... -
Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents ... -
Formulation and characterisation of polyelectrolyte complex nanoparticles for the delivery of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis explored the formulation of various polyelectrolyte complex nanoparticles as potential carriers for the delivery of macromolecules. The complexes were formed between a polyanion (hyaluroninc acid, ... -
Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy ) : a role for dopamine
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Co-administration of caffeine profoundly enhances the acute toxicity of the substituted amphetamine 3, 4-methylenedioxymethamphetamine (MDMA “Ecstasy”) in rats, evidenced by high body temperature, tachycardia and increased ... -
Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The studies in this thesis explored the solid state and inhalation properties of various systems produced by the spray drying technique. The work focused on the feasibility analysis of spray drying as a means of producing ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ...
