Pharmacy and Pharmaceutical Sciences (Scholarly Publications): Recent submissions
Now showing items 121-140 of 452
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Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways
(2018)Sample complexity and polydispersity presents challenges surrounding particle size measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the marketplace it is imperative that this task ... -
In Situ Monitoring of Nanoparticle Formation: Antisolvent Precipitation of Azole Anti-fungal Drugs.
(2018)In this work we report the effect of stabilizer choice and concentration on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredient (APIs): itraconazole (ITR), ketoconazole ... -
Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation
(2018)Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.
(2018)Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson’s disease (PD), whereas pharmacological approaches to increase noradrenaline bioavailability may ... -
Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles
(2017)A recent study showed that a significant fall in mean arterial pressure (MAP) occurred following intravenous injection of two novel superparamagnetic iron oxide nanoparticles (SPIONs), MF66 and OD15. To assess if this was ... -
Manganese: a new contrast agent for lung imaging?
(2012)Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI ... -
Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles.
(2019)There is an increasing interest in exploring clinically relevant information that is present in body fluids, and extracellular vesicles (EVs) are intrinsic components of body fluids (“liquid biopsies”). In this report, we ... -
Traditional chinese medicine from aqueous extracts to therapeutic formulae
(IntechOpen, 2019)Traditional Chinese medicine (TCM) is one of the most established systems of medicine in the world. The therapeutic formulae used in TCM are frequently derived from aqueous decoctions of single plants or complex multicomponent ... -
Density Scaling in Ionic Glass-Former Controlled by Grotthuss Conduction
(2019)We present investigations of the charge transport in an ionic glass-former carvedilol dihydrogen phosphate (CP) at various T–P–V thermodynamic conditions in terms of density scaling concept. The studied material was found ... -
Unintended discontinuation of medication following hospitalisation: a retrospective cohort study
(BMJ Publishing Group, 2019)Objectives: Whether unintended discontinuation of common, evidence-based, long-term medication occurs after hospitalisation; what factors are associated with unintended discontinuation; and whether the presence of documentation ... -
The effect of electrostatic interactions on the formation of pharmaceutical eutectics
(2018)Over the past decade, the formation of pharmaceutical eutectics has become a very attractive strategy to increase the bioavailability of active pharmaceutical ingredients (APIs). A great advantage of a eutectic phase, which ... -
Effect of electrostatic interactions on the relaxation dynamics of pharmaceutical eutectics
(2019)In this paper, we investigate the temperature-dependent relaxation dynamics in the glassy and supercooled liquid state of dipolar and ionic eutectic mixtures made of two anesthetic agents (lidocaine and prilocaine) and ... -
Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury.
(2019)Hypoxic injury of cardiovascular system is one of the most frequent complications following ischaemia. Heart injury arises from increased degradation of contractile proteins, such as myosin light chains (MLCs) and troponin ... -
Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion
(2014)In general, prodrugs are developed to circumvent deficiencies associated with the absorption, distribution, metabolism, excretion or toxicological (ADMET) profile associated with the active drug. In our study, we select ... -
Antinociceptive activity of Cistanche salsa stolons, growing in the Republic of Kazakhstan
(2017)Herba Cistanche (Cistanche species) in Traditional Chinese Medicine is used for the treatment of several diseases and symptoms, to include pain. The objective of this study was to evaluate the antinociceptive effect of the ... -
Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts
(Frontiers, 2019)Phytolacca, which belongs to the family of Phytolaccaceae, are known for their use in popular medicine.Bioactivity of five extracts from Phytolacca dioica seeds were evaluated in four bioassays. A selected groupof compounds ... -
Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug
(2014)N-methylbupropion was selected as a potential prodrug from our in vitro screening of analogues of bupropion described in the preceding paper. This study describes in vivo pharmacokinetics of N-methylbupropion in the ... -
HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential
(2019)Plant-derived polyphenols are known to have promising biological activities including antioxidant and anti-tyrosinase and may be a potential candidate for anti-dermatoheliotic remedy. The present study was performedto ... -
In Situ Cocrystallization of Dapsone and Caffeine during Fluidized Bed Granulation Processing
(American Association of Pharmaceutical Scientists ; Springer Verlag, 2019-01)Different pharmaceutical manufacturing processes have been demonstrated to represent feasible platforms for the production of pharmaceutical cocrystals. However, new methods are needed for the manufacture of cocrystals on ... -
Amorphous solid dispersions of ketoprofen and poly-vinyl polymers prepared via electrospraying and spray drying: A comparison of particle characteristics and performance.
(Elsevier, 2019-07-20)The purpose of this work was to compare the particle characteristics and dissolution performance of amorphous solid dispersions (ASDs) of ketoprofen and vinyl-pyrrolidone based polymers prepared using electrospraying and ...
