Pharmacy and Pharmaceutical Sciences (Scholarly Publications): Recent submissions
Now showing items 141-160 of 452
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A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products.
(2018)The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems ... -
Development of a new formulation of roflumilast for pulmonary drug delivery to treat inflammatory lung conditions.
(2018-10-25)The aim of this study was to develop roflumilast dry powder inhaler (DPI) formulations by spray drying using hydroxypropyl-β-cyclodextrin (HPβCD) and to determine their suitability for pulmonary delivery. Different feed ... -
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion.
(2018)The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals ... -
Production of cocrystals in an excipient matrix by spray drying
(2018-01)Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of introducing a third component into the feed solution during the ... -
Development and characterization of dapsone cocrystal prepared by scalable production methods
(American Association of Pharmaceutical Scientists ; Springer Verlag, 2018)In this study, the formation of caffeine:dapsone (CAF:DAP) cocrystals by scalable production methods, such as liquid assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed ... -
Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties
(2017)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties
(2018-05)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
(2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Receptor tyrosine kinases and drug resistance: development and characterization of in vitro models of resistance to RTK inhibitors.
(2015)Aberrant expression of receptor tyrosine kinases (RTKs) has been extensively associated with alterations in the physiological activities of cells. These include cell growth and differentiation, cell death/survival, and the ... -
Do Patients Know How to Use Sublingual Glyceryl Trinitrate?
(2011)Glyceryl trinitrate is a nitrate, a potent coronary vasodilator which exerts its principal benefit by reducing venous return, which reduces left ventricular work. Vasodilation is also associated with the undesired effects ...
