Administrative Staff Authors (Scholarly Publications): Recent submissions
Now showing items 721-740 of 828
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Microalbuminuria correlates with intestinal histopathological grading in patients with inflammatory bowel disease
(BMJ, 1996)It has previously been shown that microalbuminuria is a useful disease activity marker for inflammatory bowel disease (IBD). Microalbuminuria correlates strongly with the markers of clinical and laboratory disease activity ... -
Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation
(BMJ, 1996)BACKGROUND--Studies have suggested that expression of the adhesion molecule CD44 may be of prognostic importance in gastric cancer. In addition, there is strong evidence that Helicobacter pylori has a role in gastric cancer. ... -
Protein kinase C isotypes theta, delta and eta in human lymphocytes: differential responses to signalling through the T-cell receptor and phorbol esters
(1997)The repertoire of novel and atypical protein kinase C (PKC) isotypes present in human T cells and their subcellular localization have not been fully characterized. We detected calcium-independent PKC activity in whole cell ... -
Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells
(BMJ, 1997)BACKGROUND: Elements of the mucosal immune system may play an important part in regulating epithelial barrier function in the intestinal tract. Intraepithelial lymphocytes (IELs) represent a subtype of immunocyte which is ... -
Identification and characterization of a metalloprotease activity from Helicobacter pylori
(American Society for Microbiology, 1997)Helicobacter pylori produces a metalloprotease with a native molecular size of approximately 200 kDa, as determined by size-exclusion chromatography. Subcellular distribution studies demonstrated that the activity was ... -
Subcellular localization and translocation of protein kinase C isoforms zeta and epsilon in human peripheral blood lymphocytes
(1997)The calcium-independent members of the protein kinase C (PKC) family may play a significant role in T cell function. We have characterized the subcellular localization and redistribution of calcium-independent kinase C ... -
Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators
(American Society of Microbiology, 1998)Helicobacter pylori colonizes the gastric mucosa, and the infection is related to the development of diverse gastric pathologies, possibly by directly or indirectly affecting epithelial-cell function. We analyzed the ... -
H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control
(British Medical Association, 1998)Extracellular matrix proteins and proteins involved in epithelial adhesion are essential for maintenance of tissue structure. Helicobacter pylori is the major aetiological agent in peptic ulcer disease and has been shown ... -
Inside the crawling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes beta(I) and delta
(1998)T cells activated via integrin receptors can polarize and start crawling locomotion with repeated cycles of cytoskeletal reassembly processes, many of which depend on phosphorylation. We demonstrate that protein kinase C ... -
The thioredoxin system of Helicobacter pylori
(The American Society for Biochemistry and Molecular Biology, 2000)This paper describes the purification of thioredoxin reductase (TR) and the characterization, purification, and cloning of thioredoxin (Trx) from Helicobacter pylori. Purification, amino acid sequence analysis, and molecular ... -
Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low
(BMJ, 2000)BACKGROUND: There is concern that the incidence of non-Hodgkin's lymphoma (NHL) will rise with increasing use of immunosuppressive therapy. AIMS: Our aim was to determine the risk of NHL in a large cohort of patients with ... -
Giving Voice to the Voiceless? Second Thoughts on Testimony in Transitional Justice
(North Carolina State University, 2009)The article discusses the use of testimony as an instrument of transitional justice and the democratic value attributed to this medium. It analyzes its power structures, as well as the economies of speech of public hearings ... -
The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source
(2005)BACKGROUND AND AIMS: Chemokines are small polypeptides, a major function of which is lymphocyte recruitment and trafficking. The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and ... -
Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme
(John Wiley, 2005)Cinnamyl alcohol dehydrogenases (CAD; 1.1.1.195) catalyse the reversible conversion of p-hydroxycinnamaldehydes to their corresponding alcohols, leading to the biosynthesis of lignin in plants. Outside of plants their role ... -
Engagement of CD44 Modulates cyclooxygenase induction, VEGF generation, and cell proliferation in human vascular endothelial cells
(The Federation of American Socieites for Experimental Biology, 2005)CD44 is a receptor for hyaluronic acid and is found on the surface of hematopoetic cells and in mesenchymal tissue. It is also expressed on endothelial cells (EC). Cyclooxygenase (COX) is the rate-limiting enzyme in the ... -
Helicobacter pylori activates the early growth response 1 protein in gastric epithelial cells
(American Society for Microbiology, 2004)The early growth response 1 (Egr-1) transcription factor is rapidly induced by various stimuli and is implicated in the regulation of cell growth, differentiation, and gene expression. The aim of this study was to examine ... -
NF-kappaB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy
(Lippincott Williams & Wilkins, 2004)OBJECTIVE: To examine the expression of the transcription factor nuclear factor kappa B (NF-kappaB) in Barrett's epithelium and adenocarcinoma and the impact of NF-kappaB expression on tumor stage and response to neoadjuvant ... -
Glucocorticoid resistance in inflammatory bowel disease
(Society for Endocrinology, 2003)Glucocorticoids are potent inhibitors of T cell activation and proinflammatory cytokines and are highly effective treatment for active inflammatory bowel disease (IBD). However, failure to respond, acutely or chronically, ... -
Soluble extracts from Helicobacter pylori induce dome formation in polarized intestinal epithelial monolayers in a laminin-dependent manner
(American Society for Microbiology, 2003)Helicobacter pylori colonizes the stomach at the interface between the mucus layer and the apical pole of gastric epithelial cells. A number of secreted and shed products from the bacteria, such as proteins and lipopolysaccharide, ...
