Administrative Staff Authors (Scholarly Publications): Recent submissions
Now showing items 741-760 of 828
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A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up
(2003)BACKGROUND AND AIMS: Mutant tumour derived DNA has been detected in the sera of colorectal cancer patients. We investigated if mutant serum KRAS2 was detectable preoperatively in a large group of patients with colorectal ... -
The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen
(Nature, 2002)Epidermolysis bullosa acquisita is an autoimmune blistering disease of the skin characterized by IgG autoantibodies against type VII collagen. Systemic diseases are often associated with epidermolysis bullosa acquisita, ... -
Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis
(John Wiley, 2002)BACKGROUND: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). AIM: To evaluate the effects of 9 months of therapy with mesalazine ... -
St Johns wort increases expression of P-glycoprotein: implications for drug interactions
(Blackwell, 2002)AIMS: St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs. Co-administration with SJW has resulted in significant reductions in ... -
Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study
(BMJ, 2001)BACKGROUND AND AIMS: The benefit of 5-aminosalicylic acid therapy for maintenance of remission in Crohn's disease is controversial. The primary aim of this study was to evaluate the prophylactic properties of olsalazine ... -
Increased urinary nitrite, a marker of nitric oxide, in active inflammatory bowel disease
(Taylor and Francis, 2001)BACKGROUND: Nitric oxide (NO) production is increased in inflammatory bowel disease (IBD), and measurement of NO metabolites may be useful for monitoring disease activity. AIMS AND OBJECTIVES: To characterise urinary nitrite ... -
Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells
(BMJ, 2001)Conjugated linoleic acid (CLA) is a collective term referring to the positional and geometric isomers of linoleic acid. This novel fatty acid has been shown to have a number of beneficial actions, including immunomodulatory, ... -
Perioperative serum inflammatory response and the development of atrial fibrilation after coronary artery bypass surgery
(BMJ, 2005)Atrial fibrillation (AF) remains the most common cardiac arrhythmia and is associated with an increase in both morbidity and mortality. Some data in both the surgical and non-surgical settings suggest that inflammation has ... -
Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells
(Nature, 2005)Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. This study was designed to investigate the ... -
Sequence and phylogenetic analysis of the gene for surface layer protein, slpA, from 14 PCR ribotypes of Clostridium difficile
(Society for General Microbiology, 2006)Clostridium difficile is the commonest cause of antibiotic-associated diarrhoea, with the hospitalized elderly being at particular risk. The organism makes a crystalline surface protein layer (S-layer), encoded by the slpA ... -
Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study.
(BioMed Central, 2006)INTRODUCTION: Asymmetrical dimethyl arginine (ADMA) is an endogenous non-selective inhibitor of nitric oxide synthase that may influence the severity of organ failure and the occurrence of shock secondary to an infectious ... -
Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?
(American Academy of Paediatrics, 2007)We hypothesize that infection with the gastric pathogen Helicobacter pylori in children in developing countries is the initiator of a vicious cycle of events that result ultimately in malnutrition and growth impairment. ... -
Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells
(BioMed Central, 2009)Background The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role ... -
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
(American Society for Clinical Investigation, 2009)There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single ... -
'The future isn't what it used to be': Technology in counselling and psychotherapy
(2008)Change is prefigured in the articulation by Dr Rick Satavas: `the future isn?t what it used to be?. Its sentiment rings true; recently psychotherapy practitioners and researchers have begun investigating the potential of ... -
Monitoring of Cognitive Processes in Older Persons
(IEEE, 2009)
