RSS 1.0Microbiology
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Microbiology (Live Theses)
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Microbiology (Scholarly Publications)
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Microbiology (Theses and Dissertations)
Microbiology (Theses and Dissertations)
Recent Submissions
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Understanding how community context drives virulence-associated traits in the Cystic Fibrosis pathogen Pseudomonas aeruginosa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)The lungs of patients with Cystic Fibrosis (CF) are often chronically colonised by a plethora of microbial species, including the major CF pathogen Pseudomonas aeruginosa (P. aeruginosa). Herewith, when examining ... -
Investigating the Impact of Anthropogenic Change on Soil Microbiome Functioning and Crop Health
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)Anthropogenic change poses significant challenges for society today. Soil microbial communities are under constant anthropogenic stress from pollution, rising climates, pesticide use, and deforestation to name a few. We ... -
Characterising the small RNA-regulatory architecture of Acinetobacter baumannii
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)The Gram-negative bacterium Acinetobacter baumannii is a significant opportunistic pathogen in critically ill and hospitalised patients. It exhibits a remarkable ability to survive under harsh environmental conditions, ... -
Characterisation of the alternative sigma factor SigAB in Acinetobacter baumannii
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Acinetobacter baumannii is a priority pathogen and is known to be a leading cause of nosocomial infections worldwide. It is associated with a variety of illnesses including septicaemia, pneumonia, and urinary tract ... -
Molecular characterisation of tagO-deficient mutants of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Wall teichoic acid (W TA) is a major component of the Gram -positive bacterial cell wall. Despite not being essential, it plays important roles in cell growth, division, morphology and virulence. The enzyme TagO initiates ... -
Analysis of the mechanism of protein A release and its contribution to immune evasion by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2016)The immunoglobulin binding protein A (SpA) of Staphylococcus aureus was one of the first cell wall-associated proteins of Gram-positive bacteria to be identified and characterised. It is synthesized as a precursor with a ... -
Investigating the contributions to cell function of the different Swi-Snf complex subunits in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The eukaryotic genome is packaged as a DNA-protein structure known as chromatin. The basic subunit of chromatin is the nucleosome, which contains two copies of each of the core histone proteins H2A, H2B, H3, and H4, around ... -
Investigating a role for linker histone H1 in quiescent cells of Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The aim of this study was to determine whether either Hho1p or Hmo1p can be considered the best candidate to function as linker histone H1 in Saccharomyces cerevisiae. The hypothesis was that yeast linker histone H1 would ... -
Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
(2024)Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to avoid ... -
Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments
(2024)Pseudomonas aeruginosa is a cause of chronic respiratory tract infections in people with cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease. Prolonged infection allows the accumulation ... -
Understanding Tolerance to Biocides and its Consequences in Clinical Isolates of Klebsiella pneumoniae - How to Treat an ESKAPE Pathogen
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Biocides such as Triclosan, Benzalkonium Chloride, and Chlorhexidine have been used as disinfectants for many years, however the effects of their use and the subsequent selective pressures applied to microbial populations ... -
The transcriptional landscape and small RNAs in Acinetobacter baumannii AB5075 during antibiotic and environmental stress.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Multi-drug resistant Acinetobacter baumannii is considered a major challenge because it causes a variety of serious infections. Studying these bacteria at the level of their genetic response could facilitate finding a way ... -
Understanding benzalkonium chloride tolerance and its implications in antibiotic resistance and other phenotypes in clinical isolates of Klebsiella pneumoniae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)In this study, clinical isolates of Klebsiella pneumoniae, a Gram-negative pathogen associated with hospital acquired infections, were tested for both phenotypic and genotypic changes following adaptation to the commonly ... -
Investigating the potential to source novel postbiotics with anti-microbial or immune-modulatory activity from distillery waste
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The purpose of this project is to find a novel source for antimicrobial and immunomodulatory compounds. Here we investigate the antimicrobial and immunomodulatory potential of postbiotics sourced from whisky distillation. ... -
Preventing protein-dependent biofilm formation in Staphylococcus aureus by targeting the serine aspartate repeat protein C and fibronectin binding proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Staphylococcus aureus is a leading cause of biofilm infections on indwelling medical devices. S. aureus biofilm infections are intrinsically difficult to treat. They are recalcitrant to conventional antibiotics and resistant ... -
Ecological dependencies and the illusion of cooperation in microbial communities
(2024)Ecological dependencies - where organisms rely on other organisms for survival - are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amino acids. Legume plants ... -
Community composition drives siderophore dynamics in multispecies bacterial communities.
(2023)Background Intraspecific public goods are commonly shared within microbial populations, where the benefits of public goods are largely limited to closely related conspecifics. One example is the production of iron-scave ... -
Ecological selection of siderophore-producing microbial taxa in response to heavy metal contamination
(2018)Some microbial public goods can provide both individual and community-wide benefits, and are open to exploitation by non-producing species. One such example is the production of metaldetoxifying siderophores. Here, we ... -
No effect of intraspecific relatedness on public goods cooperation in a complex community
(2018)Many organisms—notably microbes—are embedded within complex communities where cooperative behaviors in the form of excreted public goods can benefit other species. Under such circumstances, intraspecific interactions are ... -
Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations
(2019)Transposable temperate phages randomly insert into bacterial genomes, providing increased supply and altered spectra of mutations available to selection, thus opening alternative evolutionary trajectories. Transposable ...
