School of Genetics & Microbiology: Recent submissions
Now showing items 121-140 of 911
-
Exploring the functions of PRC2 in development and congenital disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb group (PcG) proteins are key chromatin-based repressors of gene expression that play important roles in lineage-specification and cellular memory. PcG proteins assemble into multi-subunit complexes, termed Polycomb ... -
Development of gene therapies for retinal degenerations
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)The studies described in this thesis explore potential gene therapies for retinal degenerative diseases using adeno-associated virus (AAV) vectors for gene delivery. Inherited retinal degenerations (IRDs) are a leading ... -
Drug Repurposing as a Strategy to Uncover Effective Antibacterial Compounds using Salmonella as a model
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Without doubt, antimicrobial resistance (AMR) is one of the most serious global challenge for public, animals and environmental health. Tackling this huge issue that is threatening modern medicine, is an urgent priority ... -
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
(2012)Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional ... -
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
(2021)Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation ... -
Novel therapeutic approaches for open-angle glaucoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Glaucoma is the leading cause of blindness worldwide after cataracts and it is estimated that the global prevalence of glaucoma will increase to 111.8 million by 2040 (1, 2). Primary open-angle glaucoma (POAG) is characterized ... -
Investigating the interplay between the Tup1-Cyc8 and Swi-Snf chromatin remodelling complexes in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Swi-Snf is an ATP dependent chromatin remodelling complex which acts as a co-activator of gene transcription by its ability to open up densely packed chromatin by removal of nucleosomes. Conversely, Tup1-Cyc8 ... -
Impact of Metabolites on the Intestinal Mucosa and Development of Inflammation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)The intestinal epithelial mucosal barrier plays a pivotal role in the maintenance of intestinal homeostasis, acting as an important barrier between microbes and the host s innate immune system. The metabolite-rich environment ... -
Investigating the molecular mechanisms that control the transformation of leaves into floral organs.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Arabidopsis thaliana is the model plant which has been used to elucidate the molecular and genetic processes which underlie floral organogenesis. This is the process in which the four floral organs are formed which is ... -
Exceptional ancient DNA preservation and fibre remains of a Sasanian saltmine sheep mummy in Chehrābād
(2021)Mummified remains have long attracted interest as a potential source of ancient DNA. However, mummification is a rare process that requires an anhydrous environment to rapidly dehydrate and preserve tissue before complete ... -
Colony Stimulating Factor 1 Receptor and Blood-Brain Barrier Maintenance
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood-brain barrier (BBB) disruption are still not ... -
Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1
(2017)Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors ... -
Synaesthesia lost and found: two cases of person- and music-colour synaesthesia
(2017)Synaesthesia is a developmental condition involving cross-communication between sensory modalities or substreams whereby an inducer (e.g. a sound) automatically evokes a concurrent percept in another modality (e.g. a ... -
Neurogenomics - towards a more rigorous science
(2018)The field of neurogenomics is coming of age, but not without some teething problems. The aim of this field is to understand the genetic basis of differences in brain structure and function, which in turn underlie differences ... -
The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia
(2019)A recent development in the genetic architecture of schizophrenia suggested that an omnigenic model may underlie the risk for this disorder. The aim of our study was to use polygenic profile scoring to quantitatively assess ... -
Data for 3D reconstruction of the corticospinal tract in the wild-type and Semaphorin 6A knockout adult brain
(2019)The corticospinal tract (CST) has a complex and long trajectory throughout the brain. Semaphorin 6A (Sema6A), a member of the semaphorin family, is one of the important regulators of CST axon guidance. Previous studies ... -
Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice
(2019)The corticospinal tract (CST) has a complex and long trajectory that originates in the cerebral cortex and ends in the spinal cord. Semaphorin 6A (Sema6A), a member of the semaphorin family, is an important regulator of ... -
Functional characterisation of small RNAs in Acinetobacter baumannii using Hi-GRIL-seq
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Acinetobacter baumannii is a priority pathogen that is a leading source of nosocomial multidrug resistant (MDR) infections worldwide. A key to the success of A. baumannii is the ability to quickly adapt to changing ... -
Characterising the effects of sex interaction, pleiotropy and local population structure on ALS GWAS
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)In the past decade, increasingly large-scale genome wide association studies (GWAS) have gleaned insights into the genetic architecture of a range of human traits. Widespread sharing of summary statistics for these GWAS ...
